![1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene (CAS 688348-33-6) - chemical structure image](https://media.scbt.com/product/1-3-dichloro-5--e-2-4-trifluoromethyl-phenylethenylbenzene-688348-33-6-structure_26_64_b_266411.jpg)
![1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene (CAS 688348-33-6) - chemical structure image](https://media.scbt.com/product/1-3-dichloro-5--e-2-4-trifluoromethyl-phenylethenylbenzene-688348-33-6-structure_26_64_t_266411.jpg "Molecular structure of 1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene, CAS Number: 688348-33-6")
Molecular structure of 1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene, CAS Number: 688348-33-6
1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene (CAS 688348-33-6)
Alternate Names:
CAY10465
Application:
1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene is a selective, potent aryl hydrocarbon receptor agonist
CAS Number:
688348-33-6
Molecular Weight:
317.13
Molecular Formula:
C15H9Cl2F3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
1, 3- dichloro- 5- [(1E)- 2- [4- (trifluoromethyl)phenyl]ethenyl]- benzene is an analog of resveratrol which acts as a selective and potent aryl hydrocarbon (AH) receptor agonist. It is inactive as a ligand for the estrogen receptor, even at 100 muM. 1,3-Dichloro-5-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]benzene is a highly stable halogenated aromatic compound. In vitro studies utilize cell cultures or laboratory models to examine the impact of 1,3-dichloro-5-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]benzene on cellular components or other aspects of the system under investigation.
1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene (CAS 688348-33-6) References
- Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. | Denison, MS. and Nagy, SR. 2003. Annu Rev Pharmacol Toxicol. 43: 309-34. PMID: 12540743
- Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. | de Medina, P., et al. 2005. J Med Chem. 48: 287-91. PMID: 15634023
- Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. | Naem, E., et al. 2012. Life Sci. 91: 64-9. PMID: 22727790
- Resveratrol Analogs with Antioxidant Activity Inhibit Intestinal Epithelial Cancer Caco-2 Cell Growth by Modulating Arachidonic Acid Cascade. | Storniolo, CE. and Moreno, JJ. 2019. J Agric Food Chem. 67: 819-828. PMID: 30575383
- Non-nucleoside hepatitis B virus polymerase inhibitors identified by an in vitro polymerase elongation assay. | Nakajima, S., et al. 2020. J Gastroenterol. 55: 441-452. PMID: 31768802
- Pilot study of global endocrine disrupting activity in Iowa public drinking water utilities using cell-based assays. | Jones, RR., et al. 2020. Sci Total Environ. 714: 136317. PMID: 32018941
- Mapping multiple endocrine disrupting activities in Virginia rivers using effect-based assays. | Stavreva, DA., et al. 2021. Sci Total Environ. 773: 145602. PMID: 33592464
Activator of:
Aryl Hydrocarbon Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene, 1 mg | sc-221401 | 1 mg | $26.00 | |||
1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene, 5 mg | sc-221401A | 5 mg | $116.00 |