1,2-Dipalmitoyl-L-α-phosphatidyl-D-myo-inositol 4,5-bisphosphate is a 4,5-bisphosphate group on the inositol ring is critical for binding specifically to PH domains that are commonly present in signalling proteins. Also found in cytoskeleton.
Structure of the binding site for inositol phosphate in a PH domain: M. Hyvonen, et al.; EMBO J. 14, 4676 (1995) Abstract Inositolpolyphosphates and their binding proteins--a short review: B. Huisamen & A. Lochner; Mol. Cell. Biochem. 157, 229 (1996) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate: T.F. Franke, et al.; Science 275, 665 (1997) Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking: T.F. Martin; Annu. Rev. Cell. Dev. Biol. 14, 231 (1998), (Review) The synthesis and cellular roles of phosphatidylinositol 4,5- bisphosphate: A. Toker; Curr. Opin. Cell Biol. 10, 254 (1998) Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5- bisphosphate: R. Rohatgi, et al.; J. Cell Biol. 150, 1299 (2000)
See how others have used 1,2-Dipalmitoyl-L-alpha-phosphatidyl-D-myo-inositol 4,5-bisphosphate (CAS 120595-88-2). Click on the entry to view the PubMed entry .
PMID: # 28697598 Zheng, K. et al. 2017. J. Agric. Food Chem. 65: 6625-6637.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.