1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose A cell growth inhibitor

1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose  (CAS 14937-32-7)

1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose, CAS 14937-32-7 is rated 5.0 out of 5 by 1.
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Application: A cell growth inhibitor
CAS Number: 14937-32-7
Purity: ≥98%
Molecular Weight: 940.68
Molecular Formula: C41H32O26
* Refer to Certificate of Analysis for lot specific data (including water content).
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1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose (PGG) induces apoptosis in DU145 and LNCaP cells. PGG effects downstream products of (FRAP) mTOR. PGG exhibits in vitro growth-inhibiting effect on human hepatocellular carcinoma cell line, SK-HEP-1 cells. 1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose is an inhibitor of PAI-1.


References

1. Oh, G.S., et al. 2001. Cancer Lett. 174: 17-24. PMID: 11675148

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol, and water (slightly).
Storage :
Store at -20° C
Melting Point :
>180° C (dec.)
Boiling Point :
1365.7° C at 760 mmHg
Density :
~2.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.87 (Predicted)
IC50 :
Thrombin: IC50 = 50 nM (bovine); Factor X: IC50 = 170 nM (human); Squalene monooxygenase: IC50 = 470 nM (rat); Hepatitis C virus NS3 protease/helicase: IC50 = 1.6 µM (Hepatitis C virus); Xanthine dehydrogenase: IC50 = 3.2 µM (bovine)
Ki Data :
Factor X: Ki= 570 nM (human); Thrombin: Ki= 3.9 µM (bovine)
pK Values :
pKa: 8.37 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
65238
MDL Number :
MFCD03788860
Beilstein Registry :
79674
SMILES :
C1=C(C=C(C(=C1O)O)O)C(=O)OCC2C(C(C(C(O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)OC(=O)C6=CC(=C(C(=C6)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-220537, is provided as an off-white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-25
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Rated 5 out of 5 by from Kim Kim, YH. et al. (PubMed 25737197) reported that 1,2,3,4,6-Penta-O-galloyl- -D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. -SCBT Publication Review
Date published: 2015-06-28
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