1,1-Dimethylbiguanide, Hydrochloride (Metformin) is a biguanide antihyperglycemic agent. Through glucose clamp investigation in rats 1,1-Dimethylbiguanide, Hydrochloride has been shown to lower blood glucose levels through improved glucose tolerance without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. The biguanide reduces the diabetic complications on the cardiovascular system and increases insulin sensitivity. The compound has been shown not to change the synthesis of either GLUT4 or GLUT1 but does stimulate the transport of GLUT1 to the plasma membrane as seen in skeletal muscles. The compound has also been observed to improve peripheral arterials through selective reduction of PAI-1 (plasminogen activator inhibitor). In Xenopus oocytes the compound has been documented to act by increasing intercellular calcium concentration in addition to elevating receptor tyrosine kinase activity and inositol 1,4,5-trisphosphate. 1,1-Dimethylbiguanide, Hydrochloride has demonstrated the ability to induce fatty acid oxidation and to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase activity. In brown adipocytes 1,1-Dimethylbiguanide, Hydrochloride has been observed to inhibit leptin secretion via a mitogen-activated protein kinase signalling pathway.
1. Vague, P.,et al. 1987. Thromb. Haemost. 57: 326-328. PMID: 3310318
2. Rossetti, L., et al. 1990. Metab. Clin. Exp. 39: 425-435. PMID: 2157941
3. Stith, B.J., et al. 1996. Endocrinology. 137: 2990-2999. PMID: 8770923
4. Lin, H.Z., et al. 2000. Nat. Med. 6: 998-1003. PMID: 10973319
5. Zhou, G., et al. 2001. J. Clin. Invest. 108: 1167-1174. PMID: 11602624
6. Cleasby, M.E., et al. 2004. Diabetes. 53: 3258-3266. PMID: 15561958
7. Klein, J., et al. 2004. J. Endocrinol. 183: 299-307. PMID: 15531718
8. Mohiuddin, M., et al. 2009. Pak. J. Biol. Sci. 12: 734-737. PMID: 19634481
See how others have used 1,1-Dimethylbiguanide, Hydrochloride (CAS 1115-70-4). Click on the entry to view the PubMed entry .
PMID: # 30824582 Teh, JT.|Zhu, WL.|Newgard, CB.|Casey, PJ.|Wang, M.| et al. 2019. Mol. Cancer Ther. 18: 693-705.
PMID: # 30926854 Gillespie, ZE. et al. 2019. Sci Rep. 9: 5369.
PMID: # 30809021 Ferretti, AC.|Hidalgo, F.|Tonucci, FM.|Almada, E.|Pariani, A.|Larocca, MC.|Favre, C.| et al. 2019. Sci Rep. 9: 2815.
PMID: # 29958542 Furat Rencber, S.|Kurnaz Ozbek, S.|Eraldemır, C.|Sezer, Z.|Kum, T.|Ceylan, S.|Guzel, E.| et al. 2018. J Ovarian Res. 11: 55.
PMID: # 30293696 Lai, EH.|Yang, CN.|Lin, SK.|Wang, HW.|Kok, SH.|Hong, CY.|Su, IH.|Yang, H.|Chang, JZ.| et al. 2018. J Endod. 44: 1817-1825.
PMID: # 27741557 Huang, YS. et al. 2017. Biomed. Chromatogr. 31:
PMID: # 28877050 de Souza Neto, FP.|Bernardes, SS.|Marinello, PC.|Melo, GP.|Luiz, RC.|Cecchini, R.|Cecchini, AL.| et al. 2017. Melanoma Res. 27: 536-544.
PMID: # 28050601 Akinci, B. et al. 2017. Cold Spring Harb Mol Case Stud. 3: a001339.
PMID: # 28243322 García-Castillo, V. et al. 2017. J Cancer. 8: 178-189.
PMID: # 26561471 Marinello, PC. et al. 2016. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37: 5337-46.
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