Z-VDVAD-FMK MF: C32H46FN5O11
MW: 695.73
An irreversible inhibitor of Caspase-2.

Z-VDVAD-FMK

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Z-VDVAD-FMK is rated 5.0 out of 5 by 1.
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Alternate Names: Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
Application Z-VDVAD-FMK is an irreversible inhibitor of Caspase-2
분자량: 695.73
분자식: C32H46FN5O11
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Z-VDVAD-FMK (Caspase-2 inhibitor) is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. In a study of 7-ketocholesterol (sc-210630)-induced cell death and the association with polar lipid accumulation, the effects of Z-VDVAD-FMK on the lipid profile was evaluated by staining with Nile Red (sc-203747). Z-VDVAD-FMK has also been shown to inhibit programmed macrophage cell death induced by Brucella species gram-negative bacteria.

Purity: Single spot by TLC.


References

1. Vejux, A. et al. 2007. Cytometry A. 71(8): 550-562. PMID: 17458884
2. Chen, F. and He, Y. 2009. PLoS ONE. 4(8): e6830. PMID: 19714247

사용법 :
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in DMSO (13.91 mg/ml), and DMSO/DMF (20 mM).
저장 :
Store at -20° C
비등점 :
980.10° C at 760 mmHg (Predicted)
밀도 :
1.23 g/cm3 (Predicted)
굴절률 :
n20D 1.51 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD03452881
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](CC(=O)OC)NC(=O)[[email protected]](C(C)C)NC(=O)OCC1=CC=CC=C1

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분석증명서

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Z-VDVAD-FMK  논문정보

다른 사용자의 Z-VDVAD-FMK사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 4 of 4 합계

PMID: # 24204395  Wu, CC. et al. 2013. Evidence-based complementary and alternative medicine : eCAM. 2013: 548929.

PMID: # 19118032  Trougakos, IP. et al. 2009. Clin. Cancer Res. 15: 48-59.

PMID: # 19154411  Lee, JC. et al. 2009. Cancer science. 100: 503-13.

PMID: # 17082817  Hanoux, V. et al. 2007. Cell Death Differ. 14: 671-81.

인용 1 to 4 of 4 합계
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