Z-VAD(OMe)-FMK CAS: 187389-52-2
MF: C22H30FN3O7
MW: 467.49

Z-VAD(OMe)-FMK (CAS 187389-52-2)

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Alternate Names: Z-VAD(OMe)-FMK also known as Z-VAD-FMK; pan-Caspase Inhibitor; Caspase family inhibitor (fluoromethylketone); Z-Val-Ala-Asp(OMe)-fluoromethylketone; Z-VAD(OMe)-fluoromethylketone, Caspase Inhibitor (FMK); Z-Val-Ala-Asp fluoromethyl ketone
Application Z-VAD(OMe)-FMK is an irreversible and cell permeable broad-spectrum Caspase Inhibitor that has shown to inhibit caspase-1 and caspase-3
CAS 등록번호: 187389-52-2
순도: ≥95%
분자량: 467.49
분자식: C22H30FN3O7
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Z-VAD(OMe)-FMK is an irreversible and cell permeable broad-spectrum Caspase Inhibitor displaying an IC50 of 5.8 nM in HepG2 cells. Z-VAD(OMe)-FMK has been shown to inhibit caspase-1 and caspase-3. Z-VAD(OMe)-FMK also been shown to inhibit Fas-mediated apoptosis in Jurkat T cells and apoptosis in THP.1 cells induced by diverse stimuli (including cycloheximide, thapsigargin, etoposide and staurosporine). Furthermore, anti-CD95-induced hepatocyte apoptosis was prevented in a concentration-dependent manner by inhibitor Z-VAD-FMK (IC50 = 1.5 nM). Additionally, Z-VAD(OMe)-FMK has been shown that pretreatment of MDA-MB-231 and HL-60 cells with Z-VAD(OMe)-FMK also inhibits apoptosis.


References

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사용법 :
Stock solutions should be divided into aliquots and stored at -20°C for up to 1 month.
Physical State :
Solid
시퀀스 :
Z-Val-Ala-Asp(OMe)-fluoromethylketone
용해도 :
Soluble in DMSO (20 mg/ml), DMF (7 mg/ml), ethanol (1.3 mg/ml), and methanol:chloroform (1:1) (10 mg/ml). Insoluble in water.
저장 :
Store at -20° C
녹는점 :
267.59° C (Predicted)
비등점 :
732.37° C at 760 mmHg (Predicted)
밀도 :
1.21 g/cm3 (Predicted)
굴절률 :
n20D 1.51 (Predicted)
pK Values :
pKa: 11.05 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD02684037
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](C(C)C)NC(=O)OCC1=CC=CC=C1

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인용 1 to 10 of 201 합계

PMID: # 33523262  Haasler, L.|Kondadi, AK.|Tsigaras, T.|von Montfort, C.|Graf, P.|Stahl, W.|Brenneisen, P.| et al. 2021. Arch Toxicol.

PMID: # 33981211  Taritla, S.|Kumari, M.|Kamat, S.|Bhat, SG.|Jayabaskaran, C.| et al. 2021. Front Pharmacol. 12: 542891.

PMID: # 33161305  Xu, J.|Wang, L.|Zhang, L.|Zheng, F.|Wang, F.|Leng, J.|Wang, K.|Héroux, P.|Shen, HM.|Wu, Y.|Xia, D.| et al. 2020. Redox Biol. 38: 101776.

PMID: # 33073770  Kim, MJ.|Kang, YJ.|Sung, B.|Jang, JY.|Ahn, YR.|Oh, HJ.|Choi, H.|Choi, I.|Im, E.|Moon, HR.|Chung, HY.|Kim, ND.| et al. 2020. Biomol Ther (Seoul). 28: 561-568.

PMID: # 31463653  Castiello, L.|Zevini, A.|Vulpis, E.|Muscolini, M.|Ferrari, M.|Palermo, E.|Peruzzi, G.|Krapp, C.|Jakobsen, M.|Olagnier, D.|Zingoni, A.|Santoni, A.|Hiscott, J.| et al. 2019. Cancer Immunol. Immunother. 68: 1479-1492.

PMID: # 30692621  Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.

PMID: # 30967464  Giebel, AM.|Hu, S.|Rajaram, K.|Finethy, R.|Toh, E.|Brothwell, JA.|Morrison, SG.|Suchland, RJ.|Stein, BD.|Coers, J.|Morrison, RP.|Nelson, DE.| et al. 2019. MBio. 10:

PMID: # 31262874  Seo, YS. et al. 2019. Anticancer Res. 39: 3499-3506.

PMID: # 30914761  Yu, P. et al. 2019. Acta Pharmacol. Sin.

PMID: # 30795621  Nováková, J.|Talacko, P.|Novák, P.|Vališ, K.| et al. 2019. Cells. 8:

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