USP Inhibitors for functional analysis of cellular responses to USP
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
USP48 Antibody (5C2) is a high quality monoclonal USP48 antibody suitable for the detection of the USP48 protein of human origin. USP48 Antibody (5C2) is available as the non-conjugated anti-USP48 antibody. The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP48 (ubiquitin specific peptidase 48), also known as USP31 or RAP1GA1 is a widely expressed 1,035 amino acid protein that belongs to the peptidase C19 family of proteins. Containing three DUSP domains and one ubiquitin-like domain, USP48 functions as a deubiquitinating enzyme that cleaves ubiquitin residues from both ubiquitinylated proteins and ubiquitin-fused precursors, thereby saving these proteins from proteasomal degradation. By reversing the ubiquitination of proteins such as TRAF2 and TRAF6, USP48 plays an important role in the regulation of NFκB activation. Seven isoforms of USP48 are expressed due to alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.