Ubiquitin Aldehyde isopeptidase T 및 Ubiquitin C-terminal Hydrolase 활성 억제제

Ubiquitin Aldehyde

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Application Ubiquitin Aldehyde is an inhibitor of isopeptidase T and Ubiquitin C-terminal Hydrolase activity
순도: ≥95%
분자량: 8500
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Ubiquitin Aldehyde has shown to inhibit the activity of USP5 and UCH-L1. It is useful in the stabilization of ubiquitin-protein conjugates in vitro, enhancing their accumulation in cell lysates and tissue extracts. It inhibits deubiquitinylating enzyme activity and can be used to identify such activity to determine the inhibition kinetics for a particular enzyme. Ubiquitin Aldehyde is a potent, highly specific inhibitor of all ubiquitin deconjugating enzymes, including UCHs (ubiquitin C-terminal hydrolases), USPs (ubiquitin-specific proteases) and DUBs (deubiquitinylating enzymes). Concentration recommended for maximal inhibition is 2-5μM.

Formulation :
1mg/ml in water containing 0.15M HCl
Appearance :
Aqueous solution
Physical State :
Liquid
용해도 :
Soluble in aqueous buffers, DMSO (50 mg/ml), and water.
저장 :
Store at 4° C
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
EC Number :
231-791-2

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분석증명서

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Ubiquitin Aldehyde  논문정보

다른 사용자의 Ubiquitin Aldehyde사용법보기. 클릭하여 PubMed entry보기 .

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PMID: # 30532073  Liu, B. et al. 2018. Oncogene.

PMID: # 30340022  Wan, W. et al. 2018. Mol. Cell. 72: 303-315.e6.

PMID: # 28672898  Geng, Z.|Wei, L.|Zhang, C.|Yan, X.| et al. 2017. Exp Ther Med. 14: 91-96.

PMID: # 28775317  Sun, W. et al. 2017. Sci Rep. 7: 7190.

PMID: # 29084198  Hein, JB. et al. 2017. Nat. Cell Biol. 19: 1433-1440.

PMID: # 22163316  Ferrero, M. et al. 2011. PLoS ONE. 6: e28602.

PMID: # 19244336  Whitehurst, CB.|Ning, S.|Bentz, GL.|Dufour, F.|Gershburg, E.|Shackelford, J.|Langelier, Y.|Pagano, JS.| et al. 2009. J Virol. 83: 4345-53.

PMID: # 16211010  Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y. et al. 2005. EMBO J. 24: 3747-3756.

PMID: # 14559776  Burnett, B. et al. 2003. Hum. Mol. Genet. 12: 3195-3205.

PMID: # 14663138  Shackelford, J. et al. 2003. Proc. Natl. Acad. Sci. USA. 100: 15572-6.

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