Sos SH3 domain inhibitor 억제제 CAS: 159088-48-9
MF: C53H91N19O11
MW: 1170.43
A synthetic inhibitor for Sos.

Sos SH3 domain inhibitor 억제제 (CAS 159088-48-9)

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Alternate Names: Ras inhibitory peptide; VPPPVPPRRR; SOS-1 (human) (1149-1158)
Application Sos SH3 domain inhibitor is blocks Sos/GRB2 interaction, preventing Ras activation
CAS 등록번호: 159088-48-9
순도: ≥97%
분자량: 1170.43
분자식: C53H91N19O11
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* 참조분석증명서대량의 측정 데이터(함수량포함).
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Sos SH3 domain inhibitor is a biologically active peptide. The SH3 binding sequence of Sos which blocks Sos/GRB2 interaction, preventing Ras activation via receptor protein tyrosine kinases.


References

1. Goudreau, N., et al., 1994. NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos. Nature structural biology. 1(12): 898-907. PMID: 7773779
2. Li, N., et al., 1993. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 363(6424): 85-8. PMID: 8479541
3. Vidal, M., et al., 2004. Design of peptoid analogue dimers and measure of their affinity for Grb2 SH3 domains. Biochemistry. 43(23): 7336-44. PMID: 15182177
4. Jacquot, Yves., et al., 2007. High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide. Bioorganic & medicinal chemistry. 15(3): 1439-47. PMID: 17113302
5. Ho, Pei-Yin., et al., 2006. Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. Molecular cancer therapeutics. 5(12): 3130-8. PMID: 17172416

Appearance :
Lyophilized powder
Physical State :
Solid
시퀀스 :
Val-Pro-Pro-Pro-Val-Pro-Pro-Arg-Arg-Arg
용해도 :
Soluble in water.
저장 :
Store at -20° C
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.

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PMID: # 21067705  2011. Microvasc. Res. 81: 135-42.

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