Senktide CAS: 106128-89-6
MF: C40H55N7O11S
MW: 841.97
A tachykinin NK-3 receptor agonist.

Senktide (CAS 106128-89-6)

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Application Senktide is a tachykinin NK-3 receptor agonist
CAS 등록번호: 106128-89-6
순도: ≥95%
분자량: 841.97
분자식: C40H55N7O11S
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* 참조분석증명서대량의 측정 데이터(함수량포함).
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Senktide is shown to selectively interact with a tachykinin receptor subtype (SP-N) and can be used in studies to find out the regulation, distribution, and functional role of this receptor. This compound is also reported to be an NK-3R agonist and may cause behavior similar to serotonergic stimulation in murine models. NK-3R (tachykinin NK-3 receptors) have been noted to mediate bronchoconstriction in guinea pig lungs, and activation of these receptors by Senktide has also been shown to induce bronchoconstriction. Furthermore, this agent has demonstrated the ability to induce increased numbers of Fos-LI neurons in numerous regions of the guinea pig brain.


References

1. Laufer, R., et al. 1986. J. Biol. Chem. 261: 10257-10263. PMID: 2426259
2. Stoessl, A.J., et al. 1987. Neurosci. Lett. 80: 321-326. PMID: 2446214
3. Dam, T.V., et al. 1990. Brain Res. 506: 175-179. PMID: 1689199
4. Corboz, M.R., et al. 2010. Exp. Lung Res. 36: 509-521. PMID: 20939761

Physical State :
Solid
시퀀스 :
Succinyl-Asp-Phe-(N-Me)-Phe-Gly-Leu-Met-NH2
용해도 :
Soluble in methanol (25 mg/ml), ethanol (25 mg/ml), and DMSO (25 mg/ml).
저장 :
Store at -20° C
비등점 :
1262.64° C at 760 mmHg
밀도 :
1.29 g/cm3
굴절률 :
n20D 1.58
IC50 :
Tachykinin receptor 3: EC5050 = 0.5 nM (rat); NK3 receptor: EC5050 = 3 nM (human); NK3 receptor: IC50 = 0.02 µM (human); achykinin receptor 3: IC50 = 0.01 µM (guinea pig)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
SMILES :
CC(C)C[[email protected]@H](C(=O)N[[email protected]@H](CCSC)C(=O)N)NC(=O)CNC(=O)[[email protected]](CC1=CC=CC=C1)N(C)C(=O)[[email protected]](CC2=CC=CC=C2)NC(=O)[[email protected]](CC(=O)O)NC(=O)CCC(=O)O

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분석증명서

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