(S)-HexylHIBO is a group I mGluR antagonist and enantiomer of hexylHIBO (sc-203597). Metabotropic glutamate receptors (mGluR) are divided into three groups; group I, group II, and group III. Group I (mGluR-1 and mGluR-5) receptors are coupled to Gq/11 and are activators of phospholipase C. (S)-HexylHIBO is a group I mGluR antagonist which include metabotropic glutamate receptor subtypes mGluR-1 and mGluR-5.
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