NSC 625987 CAS: 141992-47-4
MF: C15H13NO2S
NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor.

NSC 625987 (CAS 141992-47-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 119ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Alternate Names: 1,4-Dimethoxy-9(10H)-acridinethione
Application NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor
CAS 등록번호: 141992-47-4
순도: ≥95%
분자량: 271.33
분자식: C15H13NO2S
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
loading

NSC 625987 is a Cdk4 (cyclin-dependent kinase (cdk) 4) inhibitor (IC50 = 0.2 μM at Cdk4 (cdk4)/cyclin D1). The compound displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).


References

Kubo et al (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 5 4279. McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competit

Physical State :
Solid
용해도 :
Soluble in DMSO (25 mg/ml), and ethanol (2.5 mg/ml).
저장 :
Store at 4° C
녹는점 :
182.57° C (Predicted)
비등점 :
460.38° C at 760 mmHg (Predicted)
밀도 :
~1.3 g/cm3 (Predicted)
굴절률 :
n20D 1.68 (Predicted)
IC50 :
Cdk4/cyclin D1: IC50 = 0.2 µM; Cdk1/cyclin A: IC50 > 100 µM; Cdk2/cyclin A: IC50 > 100 µM; Cdk2/cyclin E: IC50 > 100 µM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD08276925
SMILES :
COC1=C2C(=C(C=C1)OC)NC3=CC=CC=C3C2=S

SDS(MSDS)다운로드

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 124ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

산타크루즈바이오테크놀러지는 생물의학연구에 필요한 제품을 개발하는 선구자입니다. Toll Free 1-800-457-3801로 연락주세요. Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. 판권소유. "Santa Cruz Biotechnology", 와 Santa Cruz Biotechnology, Inc. 로고, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", 및 San Juan Ranch 로고, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz"와 "EZ Touch" 는 Santa Cruz Biotechnology, Inc의 등록된 상표입니다. 모든 상표는 각자 소유주의 소유입니다.