raised against the transmembrane domain of Mucin 4 of rat Mucin 4
안티-Mucin 4/MUC4 항체 (1G8)는 WB, IP, IF and IHC(P)으로 mouse, rat and human유래의 Mucin 4 를 감지하는 데에 추천한다.
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-Mucin 4/MUC4 항체 (1G8)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Mucin 4/MUC4 Antibody (1G8) for WB and IHC(P) applications. These reagents are now offered in bundles with Mucin 4/MUC4 Antibody (1G8) (see ordering information below).
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Mucin 4 Antibody (1G8) is a high quality monoclonal Mucin 4 antibody (also designated mucin 4, cell surface associated antibody or MUC4 antibody) suitable for the detection of the Mucin 4 protein of mouse, rat and human origin. Mucin 4 Antibody (1G8) is available as both the non-conjugated anti-Mucin 4 antibody form, as well as multiple conjugated forms of anti-Mucin 4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 4, a membrane-bound mucin, is the human homolog of the rat sialomucin complex (SMC). Mucin 4 protein consists of Mucin 4α, a large amino mucin type subunit, and Mucin 4β, a transmembrane subunit containing three EGF-like domains. The Mucin 4 gene is the predominant mucin gene expressed in the normal urothelium and is also expressed in several normal tissues such as trachea, lung and testis. Dysregulation of Mucin 4 results in high levels of expression in pancreatic tumors and tumor cell lines. Induction of Mucin 4 in pancreatic carcinoma by all-trans-retinoic acid is mediated through the retinoic acid receptor-α signaling pathway. TGFβ2 serves as an interim mediator of this regulated expression. Alternative splicing in the 3′-end of the Mucin 4 gene generates at least 12 splice variants, which are characterized as two distinct types, a secreted type and a membrane-associated type. Mucin 4 protein acts as a heterodimeric bifunctional cell-surface glycoprotein and forms thick mucous effusion in the diseased middle ear.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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