Minoxidil (U-10858) CAS: 38304-91-5
MF: C9H15N5O
MW: 209.3
A selective ATP dependent K+ (Kir6) channel activator.

Minoxidil (U-10858) (CAS 38304-91-5)

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Alternate Names: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide; 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide; 2,4-Diamino-6-piperidinopyrimidine 3-N-oxide
Application Minoxidil (U-10858) is a selective ATP dependent K+ (Kir6) channel activator
CAS 등록번호: 38304-91-5
분자량: 209.3
분자식: C9H15N5O
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* 참조분석증명서대량의 측정 데이터(함수량포함).
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Minoxidil (U-10858) is a selective ATP dependent K+ channel (Kir6) activator. As a result membrane permeability increases the flow of K+ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in arteriolar smooth muscle. Alternate studies indicate that Minoxidil (U-10858) activates the β-catenin pathway in human dermal papilla cells which results in accumulation of β-catenin in the nucleus.


References

1. Meisheri, K.D., et al. 1988. J. Pharmacol. Exp. Ther. 245: 751-760. PMID: 3385640
2. Kwack, M.H., et al. 2011. J. Dermatol. Sci. 62: 154-159. PMID: 21524889

Physical State :
Solid
용해도 :
Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
저장 :
Store at room temperature
녹는점 :
272-274° C (dec.)
비등점 :
~351.7° C at 760 mmHg (Predicted)
밀도 :
~1.5 g/cm3 (Predicted)
굴절률 :
n20D 1.72 (Predicted)
pK Values :
pKa: 4.61
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
UV8200000
PubChem CID :
Merck Index :
14: 6203
MDL Number :
MFCD00063409
EC Number :
253-874-2
SMILES :
C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O

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