Melittin, an antibacterial originally derived from Apis mellifera, has been reported to cause apoptosis via induction of reactive oxygen species production in cells. Additionally, this compound has been found to suppress 4α-Phorbol 12-myristate 13-acetate (sc-202021) induced invasion of proliferative cells via inhibition of activator protein-1 and NF-κB. Other experiments show Melittin to be able to also suppress PMA-induced phosphorylation of ERK and JNK mitogen-activated protein kinases. This compound also activates phospholipase A2 (PLA2).
1. Han, S., et al. 2009. J Asian Nat Prod Res. 11: 796-804. PMID: 20183327
2. Park, C., et al. 2010. Biochem. Biophys. Res. Commun. 394: 170-172. PMID: 20188067
3. Park, J.H., et al. 2010. Mol. Cells. 29: 209-215. PMID: 20082219