안티-GABP- beta 1/2 항체 (E-1)는 WB, IP, IF and ELISA으로 mouse, rat and human유래의 GABP-β1 and GABP-β2 를 감지하는 데에 추천한다.; 이외에, canine and porcine등 species와 반응할수 있습니다
IP를 위해 agarose ;WB, IHC(P) and ELISA를 위해 HRP ;또는 IF, IHC(P) and FCM를 위해 phycoerythrin or FITC 에 결합된 Anti-GABP- beta 1/2 항체 (E-1)를 제공한다.
WB (RGB), IF, IHC(P) 와FCM, RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647결합제품도 있습니다.
WB (NIR), IF와FCM,Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems에 사용가능한 Alexa Fluor® 680 or Alexa Fluor® 790 결합제품도 있습니다.
ChIP 에 사용하는 TransCruz시약(sc-271531 X, 200 µg/0.1 ml)이 있습니다.
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) is the preferred secondary detection reagent for GABP-β1/2 Antibody (E-1) for WB applications. This reagent is now offered in a bundle with GABP-β1/2 Antibody (E-1) (see ordering information below).
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GABP-β1/2 Antibody (E-1) is a high quality monoclonal GABP- beta 1/2 antibody (also designated GABP-β1/2 antibody) suitable for the detection of the GABP- beta 1/2 protein of mouse, rat and human origin. GABP-β1/2 Antibody (E-1) is available as both the non-conjugated anti-GABP- beta 1/2 antibody form, as well as multiple conjugated forms of anti-GABP- beta 1/2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The transcription factor GA-binding protein (GABP) is composed of two subunits, the Ets-related GABP-α and a GABP-α-associated subunit, GABPβ. GABPα binds to a specific DNA sequence and GABPβ exists as b1 and b2 splice variants that differ in their C-termini. In primary neuronal cultures, GABPβ is expressed in both the cytoplasm and the nucleus, whereas GABPα is expressed mainly in the nucleus. GABP is constitutively expressed as either a GABPαβ heterodimer or a GABPαb heterotetramer, both of which can modify GABP-dependent transcription in vitro and in vivo. The GABPαβ tetrameric complex performs many different functions, such as stimulating transcription of the adenovirus E4 gene, differentially activating BRCA1 expression in human breast cell lines, potentiating Tat-mediated activation of long terminal repeat promoter transcription and viral replication in certain cell types, acting as a coordinator of mitochrondrial and nuclear transcription for cytochrome oxidase in neurons and assisting in the regulation of rpL32 gene transcription.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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