Flavopiridol CAS: 146426-40-6
Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs.

Flavopiridol (CAS 146426-40-6)

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Alternate Names: Alvocidib
Application Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs
CAS 등록번호: 146426-40-6
순도: ≥98%
분자량: 401.84
분자식: C21H20ClNO5
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Flavopiridol is a synthetic flavone compound that inhibits the phosphorylation of cyclin-dependent kinases (Cdks) and suppresses expression of cyclin D1 and D3, interrupting the central role of Cdks in the regulation of the cell cycle and consequently promoting apoptosis. This action has been exploited in studies investigating the suppression of oncogenic proliferation, synovial hyperplasia, and joint destruction related to rheumatoid arthritis. Flavopiridol is an inhibitor of Cdk1, Cdk10, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8 and Cdk9.


References

1. De Azevedo, W.F., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 2735-2740. PMID: 8610110

2. Patel, V., et al. 1998. J. Clin. Invest. 102: 1674-1681. PMID: 9802881

3. Sekine, C., et al. 2008. J. Immunol. 180: 1954-1961. PMID: 18209094

Appearance :
Powder
Physical State :
Solid
에서 유래된 :
Synthetic
용해도 :
Soluble in chloroform, and water (slightly soluble).
저장 :
Store at 4° C
비등점 :
603.56° C at 760 mmHg (Predicted)
밀도 :
1.45 g/cm3 (Predicted)
굴절률 :
n20D 1.67 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
Merck Index :
14: 4094
MDL Number :
MFCD00894265
SMILES :
CN1CC[[email protected]@H]([[email protected]@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

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Flavopiridol (CAS 146426-40-6)  논문정보

다른 사용자의 Flavopiridol (CAS 146426-40-6)사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 10 of 38 합계

PMID: # 33529165  Patel, PS.|Abraham, KJ.|Guturi, KKN.|Halaby, MJ.|Khan, Z.|Palomero, L.|Ho, B.|Duan, S.|St-Germain, J.|Algouneh, A.|Mateo, F.|El Ghamrasni, S.|Barbour, H.|Barnes, DR.|Beesley, J.|Sanchez, O.|Berman, HK.|Brown, GW.|Affar, EB.|Chenevix-Trench, G.|Antoniou, AC.|Arrowsmith, CH.|Raught, B.|Pujana, MA.|Mekhail, K.|Hakem, A.|Hakem, R.| et al. 2021. J Clin Invest. 131:

PMID: # 31590445  2019. Cells. 8:

PMID: # 30857869  Stretton, C.|Lipina, C.|Hyde, R.|Cwiklinski, E.|Hoffmann, TM.|Taylor, PM.|Hundal, HS.| et al. 2019. Biochim Biophys Acta Mol Cell Res.

PMID: # 30745144  Levasseur, MD. et al. 2019. Dev. Cell.

PMID: # 30257893  Monda, JK.|Cheeseman, IM.| et al. 2018. Open Biol. 8:

PMID: # 30454645  Zhang, H. et al. 2018. Cell. 175: 1244-1258.e26.

PMID: # 28844864  Conrad, RJ. et al. 2017. Mol. Cell. 67: 1001-1012.e6.

PMID: # 28504701  Shao, W.|Zeitlinger, J.| et al. 2017. Nat. Genet. 49: 1045-1051.

PMID: # 29036442  Lashgari, A.|Millau, JF.|Jacques, PÉ.|Gaudreau, L.| et al. 2017. Nucleic Acids Res. 45: 12715-12722.

PMID: # 28560460  Okada, Y. et al. 2017. Oncol. Rep. 38: 31-42.

인용 1 to 10 of 38 합계
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