Desipramine hydrochloride CAS: 58-28-6
MF: C18H22N2•HCl
MW: 302.84

Desipramine hydrochloride (CAS 58-28-6)

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Alternate Names: N-(gamma-Methylaminopropyl)iminodibenzyl hydrochloride
Application Desipramine hydrochloride is an inhibitor of norepinephrine, serotonin, and dopamine transporters
CAS 등록번호: 58-28-6
순도: ≥98%
분자량: 302.84
분자식: C18H22N2•HCl
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Desipramine HCl is a selective inhibitor of noradrenaline the transporters norepinephrine transporter (SLC6A2 or NET; Ki = 4 nM), serotonin transporter (ST or SERT; Ki = 61 nM), and dopamine transporter (DAT; Ki = 78,720 nM). This compound is a potent inhibitor of the norepinephrine transporter, and also blocks serotonin re-uptake. This compound has also been shown to reverse the pro-apoptotic effect of chronic unpredictable mild stress in the rat cerebral cortex, although it induces apoptosis in several cancer cell lines. It has also been shown to display antiinflammatory activity in a rat colitis model.


References

1. Checkley, S.A., et al. 1981. Br J Psychiatry. 138: 248-251. PMID: 6268238

2. Potter, W.Z., et al. 1981. Psychopharmacol Bull. 17: 26-29. PMID: 6453356

3. Zhu, M.Y., et al. 1998. J. Neurochem. 70: 1547-1555. PMID: 9523572

4. Okugawa, G. et al. 1999. J. Neuroendocrinol. 11: 887-895. PMID: 10520140

5. Smith, N.C. and Levi, R. 1999. J. Pharmacol. Exp. Ther. 291: 456-463. PMID: 10525059

6. Zhao, Z., et al. 2008. Neuropsychopharmacology. 33: 3190-3200. PMID: 18418364

7. Bachis, A., et al. 2008. Neurosci. Lett. 442: 104-108. PMID: 18621098

Physical State :
Solid
용해도 :
Soluble in water (>25 mg/ml), alcohol, and methanol.
저장 :
Store at room temperature
녹는점 :
214-218° C
IC50 :
Serotonin transporter: IC50 = 2.5 nM
Ki 데이타 :
SLC6A2 : Ki= 4 nM; ST: Ki= 61 nM; DAT: Ki= 78720 nM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
HO0525000
PubChem CID :
Merck Index :
14: 2920
MDL Number :
MFCD00058108
EC Number :
200-373-1
SMILES :
CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

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Desipramine hydrochloride (CAS 58-28-6)  논문정보

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PMID: # 29030399  2018. FASEB J. 32: 782-794.

PMID: # 28587819  Benham, RS. et al. 2017. Behav. Brain Res. 332: 172-179.

PMID: # 27080063  Reimets, R. et al. 2016. Behavioural brain research. 308: 53-63.

PMID: # 26100518  Lin, PH. et al. 2015. J. Biomed. Sci. 22: 44.

PMID: # 26449523  Toxicology. 17-29.

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