delta17-Prostaglandin E1 CAS: 7046-45-9
MF: C20H32O5
MW: 352.5
A naturally occurring E-series prostaglandin produced by the COX metabolism of ω-3 arachidonic acid.

δ17-Prostaglandin E1 (CAS 7046-45-9)

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Application Δ17-Prostaglandin E1 is a naturally occurring E-series prostaglandin produced by the COX metabolism of ω-3 arachidonic acid
CAS 등록번호: 7046-45-9
분자량: 352.5
분자식: C20H32O5
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* 참조분석증명서대량의 측정 데이터(함수량포함).

A naturally occurring E-series prostaglandin produced by the COX metabolism of ω-3 arachidonic acid. It was first isolated and characterized as a product of ram seminal vesicle microsomes. The relative abundance of Δ17-PGE1 in humans and other animals is low in comparison with PGE2, and is likely to be a reflection of precursor fatty acid abundance in the phospholipid PUFA reservoir. Definitive studies on the biosynthesis of Δ17-PGE1 in intact animals have not been done. Δ17-PGE1 is about half as potent as PGE1 as an inhibitor of ADP-induced aggregation of rabbit PRP. In human PRP, Δ17-PGE1 is a more potent antiplatelet agonist than PGE1, with an IC50 of about 30 nM.3 The vascular effects of Δ17-PGE1 have not been reported.


References

1. Samel, N., et al. 1987. Prostaglandins. 33: 137-146. PMID: 3473571
2. Kobzar, G., et al. 1993. Comp Biochem Physiol C. 106: 489-494. PMID: 7904921
3. Kobzar, G., et al. 1991. Comp Biochem Physiol C. 40: 179-180. PMID: 7904921

Physical State :
Solid
저장 :
Store at -20° C
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :
CCC=CCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O

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