m-IgGκ BP-HRP is the preferred secondary detection reagent for DBC-1 Antibody (H-2) for WB and IHC(P) applications. This reagent is now offered in a bundle with DBC-1 Antibody (H-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
DBC-1 Antibody (H-2) is a high quality monoclonal DBC-1 antibody (also designated DBC-1 antibody) suitable for the detection of the DBC-1 protein of mouse, rat and human origin. DBC-1 Antibody (H-2) is available as the non-conjugated anti-DBC-1 antibody. DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8 (8p21-8p23) that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNFα, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNFα-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ERα, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.