DAMGO CAS: 78123-71-4
MF: C26H35N5O6
MW: 513.59
A highly selective peptide agonist for the mu-opioid receptor.

DAMGO (CAS 78123-71-4)

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Alternate Names: [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin; DAGO
Application DAMGO is a highly selective peptide agonist for the mu-opioid receptor
CAS 등록번호: 78123-71-4
분자량: 513.59
분자식: C26H35N5O6
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).
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DAMGO is a highly selective peptide agonist for the μ opioid receptor.
Sequence: YAGFG (Modifications: Ala-2 = D-Ala, Phe-4 = N-methyl-Phe, Gly-5 = Gly-ol)

Physical State :
Solid
시퀀스 :
Tyr-D-Ala-Gly-NMe-Phe-Gly-ol
용해도 :
Soluble in water (2 mg/ml).
저장 :
Desiccate at -20° C
비등점 :
~922.7° C at 760 mmHg (Predicted)
밀도 :
~1.3 g/cm3 (Predicted)
IC50 :
MOR-1: IC50 = 0.68 nM (human); Mu opioid receptor: IC50 = 1.01 nM (rat); DOR-1: IC50 = 1.45 nM (human); Cavia porcellus: IC50 = 8.25 nM; Mu opioid receptor: IC50 = 11.5 nM (Cavia porcellus)
Ki 데이타 :
MOR-1: Ki= 0.28 nM (human); Mu opioid receptor: Ki= 0.53 nM (rat); DOR-1: Ki= 0.66 nM (human); Mu opioid receptor: Ki= 0.99 nM (Cavia porcellus); CCK-BR: Ki= 11 nM (human)
pK Values :
pKa: 9.97 (Predicted), pKb: 7.24 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :
C[[email protected]](C(=O)NCC(=O)N(C)[[email protected]@H](CC1=CC=CC=C1)C(=O)NCCO)NC(=O)[[email protected]](CC2=CC=C(C=C2)O)N

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DAMGO (CAS 78123-71-4)  논문정보

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PMID: # 30758996  Am J Physiol Cell Physiol. C632-C640.

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