D-Ala-D-Ala CAS: 923-16-0
MF: C6H12N2O3
MW: 160.17
A biologically active peptide used for affinity chromatography and binding mechanism studies.

D-Ala-D-Ala (CAS 923-16-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 99ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Alternate Names: 2-[(2-ammoniopropanoyl)amino]propanoate; D-alanyl-D-alanine
Application D-Ala-D-Ala is a biologically active peptide used for affinity chromatography and binding mechanism studies
CAS 등록번호: 923-16-0
분자량: 160.17
분자식: C6H12N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

D-Ala-D-Ala is a biologically active peptide used for affinity chromatography and binding mechanism studies of antibiotics such as teicoplanin, ristocetin, and vancomycin.


References

1. Quinn, Ryan K., Cianci, Amelia L., Beaudoin, Jennifer A., Sculimbrene, Bianca R., 2010. Synthesis of a D-Ala-D-Ala peptide isostere via olefin cross-metathesis and evaluation of vancomycin binding. Bioorganic & medicinal chemistry letters. 20(15): 4382-5. PMID: 20594838 2. Xie, Jian., Pierce, Joshua G., James, Robert C., Okano, Akinori., Boger, Dale L., 2011. A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria. Journal of the American Chemical Society. 133(35): 13946-9. PMID: 21823662 3. Putty, Sandeep., Rai, Aman., Jamindar, Darshan., Pagano, Paul., Quinn, Cheryl L., Mima, Takehiko., Schweizer, Herbert P., Gutheil, William G., 2011. Characterization of d-boroAla as a novel broad-spectrum antibacterial agent targeting d-Ala-d-Ala ligase. Chemical biology & drug design. 78(5): 757-63. PMID: 21827632 4. Xie, Jian., Okano, Akinori., Pierce, Joshua G., James, Robert C., Stamm, Simon., Crane, Christine M., Boger, Dale L., 2012. Total synthesis of [Ψ[C(=S)NH]Tpg4]vancomycin aglycon, [Ψ[C(=NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding. Journal of the American Chemical Society. 134(2): 1284-97. PMID: 22188323 5. Kwun, Min Jung., Novotna, Gabriela., Hesketh, Andrew R., Hill, Lionel., Hong, Hee-Jeon., 2013. In vivo studies suggest that induction of VanS-dependent vancomycin resistance requires binding of the drug to D-Ala-D-Ala termini in the peptidoglycan cell wall. Antimicrobial agents and chemotherapy. 57(9): 4470-80. PMID: 23836175

Physical State :
Solid
저장 :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :

SDS(MSDS)다운로드

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 129ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;