Colivelin CAS: 867021-83-8
MF: C119H206N32O35
MW: 2645.13

Colivelin (CAS 867021-83-8)

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Alternate Names: Colivelin is also known as H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH.
Application Colivelin is a potent, synthetic, neuroprotective peptide and activator of STAT3, increasing STAT3 phosphorylation in vitro and in vivo.
CAS 등록번호: 867021-83-8
분자량: 2645.13
분자식: C119H206N32O35
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Colivelin suppresses neuronal death by activating STAT3 in vitro. Colivelin protects against β-amyloid neurotoxicity. Colivelin also upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer′s disease (AD) models. Colivelin prevents alcohol-induced apoptosis in a fetal mouse model. Colivelin is considered a brain penetrant. Colivelin is also known as H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH, and L-seryl-L-alanyl-L-leucyl-L-leucyl-L-arginyl-L-seryl-L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-alanylglycyl-L-alanyl-L-seryl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-proline.

Physical State :
Solid
시퀀스 :
SALLRSIPAPAGASRLLLLTGEIDLP; H - Ser - Ala - Leu - Leu - Arg - Ser - Ile - Pro - Ala - Pro - Ala - Gly - Ala - Ser - Arg - Leu - Leu - Leu - Leu - Thr - Gly - Glu - Ile - Asp - Leu - Pro - OH
용해도 :
Soluble in 30% acetonitrile / water (1 mg/ml).
저장 :
Store at -20° C
밀도 :
1.42 g/cm3 (Predicted)
굴절률 :
n20D 1.63 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
MDL Number :
MFCD08704663
SMILES :
CC[[email protected]@H](C)[[email protected]@H](C(=O)N[[email protected]](CC(=O)O)C(=O)N[[email protected]@H](CC(C)C)C(=O)N1CCC[[email protected]@H]1C(=O)O)NC(=O)[[email protected]](CCC(=O)O)NC(=O)CNC(=O)[[email protected]]([[email protected]@H](C)O)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]@H](CC(C)C)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]@H](CC(C)C)NC(=O)[[email protected]](CCCNC(=N)N)NC(=O)[[email protected]](CO)NC(=O)[[email protected]](C)NC(=O)CNC(=O)[[email protected]@H](C)NC(=O)[[email protected]]2CCCN2C(=O)[[email protected]](C)NC(=O)[[email protected]]3CCCN3C(=O)[[email protected]]([[email protected]](C)CC)NC(=O)[[email protected]](CO)NC(=O)[[email protected]@H](CCCNC(=N)N)NC(=O)[[email protected]@H](CC(C)C)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]@H](C)NC(=O)[[email protected]@H](CO)N

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Colivelin (CAS 867021-83-8)  논문정보

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PMID: # 33769466  Fu, M.|Tan, L.|Lin, Z.|Lui, V.|Tam, PKH.|Lamb, J.|Zhang, Y.|Xia, H.|Zhang, R.|Chen, Y.| et al. 2021. Clin Sci (Lond).

PMID: # 33707115  Ruan, Z.|Liang, M.|Shang, L.|Lai, M.|Deng, X.|Su, X.| et al. 2021. Pancreatology. 21: 630-641.

PMID: # 29708510  Ubil, E. et al. 2018. J. Clin. Invest. 128: 2356-2369.

PMID: # 30323565  Chen, L. et al. 2018. Drug Des Devel Ther. 12: 3335-3342.

PMID: # 26045134  Quévrain, E. et al. 2016. Gut. 65: 415-25.

PMID: # 33222697  J Exp Clin Cancer Res. 252.

PMID: # 30425517  Onco Targets Ther. 11: 7255-7270.

PMID: # 27616741  Kidney Int. 1285-1297.

PMID: # 32618105  J Cell Mol Med.

PMID: # 31452742  Oncol Lett. 18: 2554-2559.

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