Cathepsin L inhibitor 억제제 CAS: 167498-29-5
MF: C26H26N2O5
MW: 446.49
A potent and reversible inhibitor of Cathepsin L.

Cathepsin L inhibitor 억제제 (CAS 167498-29-5)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 111ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Cathepsin L inhibitor 억제제 is rated 5.0 out of 5 by 1.
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: Cathepsin L inhibitor II; Z-Phe-Tyr-CHO
Application Cathepsin L inhibitor is a potent and reversible inhibitor of Cathepsin L
CAS 등록번호: 167498-29-5
순도: ≥95%
분자량: 446.49
분자식: C26H26N2O5
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
loading

Cathepsin L inhibitor (Z-FY-CHO) is a potent and selective inhibitor of Cathepsin L. In the pit formation assay with unfractionated rat bone cells, 1.5 nM of Z-FY-CHO markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption. In ovariectomized mice, it suppressed at 2.5-10 mg/kg/day ip for four weeks bone weight loss dose-dependently.


References

1. Woo, J T., Yamaguchi, K., Hayama, T., Kobori, T., Sigeizumi, S., Sugimoto, K., Kondo, K., Tsuji, T., Ohba, Y., Tagami, K., Sumitani, K., 1996. Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo. European journal of pharmacology. 300(1-2): 131-5. PMID: 8741178
2. Wille, Aline., Gerber, Annegret., Heimburg, Anke., Reisenauer, Anita., Peters, Christoph., Saftig, Paul., Reinheckel, Thomas., Welte, Tobias., Bühling, Frank., 2004. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. Biological chemistry. 385(7): 665-70. PMID: 15318816
3. Kaasik, Allen., Rikk, Tiina., Piirsoo, Andres., Zharkovsky, Tamara., Zharkovsky, Alexander., 2005. Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. The European journal of neuroscience. 22(5): 1023-31. PMID: 16176344

사용법 :
For long-term storage, store lyophilized peptide dessicated at -20°C. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Appearance :
Powder
Physical State :
Solid
시퀀스 :
Z-Phe-Tyr-CHO
용해도 :
Soluble in DMSO (50 mg/ml), or ethanol (50 mg/ml).
저장 :
Store at -20° C
녹는점 :
278.93° C (Predicted)
비등점 :
~726.5° C at 760 mmHg (Predicted)
밀도 :
~1.2 g/cm3 (Predicted)
굴절률 :
n20D 1.61 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :
C1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=C(C=C2)O)C=O)NC(=O)OCC3=CC=CC=C3

SDS(MSDS)다운로드

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

Cathepsin L inhibitor 억제제 (CAS 167498-29-5)  논문정보

다른 사용자의 Cathepsin L inhibitor 억제제 (CAS 167498-29-5)사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 10 of 13 합계

PMID: # 31223289  Mao, Z.|Sang, MM.|Chen, C.|Zhu, WT.|Gong, YS.|Pei, DS.| et al. 2019. Int. J. Biol. Sci. 15: 1310-1324.

PMID: # 28121218  Mizunoe, Y.|Sudo, Y.|Okita, N.|Hiraoka, H.|Mikami, K.|Narahara, T.|Negishi, A.|Yoshida, M.|Higashibata, R.|Watanabe, S.|Kaneko, H.|Natori, D.|Furuichi, T.|Yasukawa, H.|Kobayashi, M.|Higami, Y.| et al. 2017. Autophagy. 13: 642-653.

PMID: # 27729455  2016. J. Biol. Chem. 291: 24779-24786.

PMID: # 26730950  Markosyan, RM. et al. 2016. PLoS pathogens. 12: e1005373.

PMID: # 25108379  Shivanna, V. et al. 2014. Virology. 464-465: 287-95.

PMID: # 23438485  Ma, L. et al. 2013. Journal of proteome research. 12: 1924-34.

PMID: # 17940194  2008. Molecular pharmacology. 73: 147-56.

PMID: # 18255115  Gorria, M. et al. 2008. Toxicol. Appl. Pharmacol. 228: 212-224.

PMID: # 31925528  Inflamm. Res. 69: 267-278.

PMID: # 32364250  Prostate.

인용 1 to 10 of 13 합계
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 119ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;