Caspase-3 Inhibitor 억제제 Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10.

Caspase-3 Inhibitor 억제제 (CAS 210344-95-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 120ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Caspase-3 Inhibitor 억제제 is rated 5.0 out of 5 by 1.
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: Z-DEVD-FMK
Application Caspase-3 Inhibitor is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS 등록번호: 210344-95-9
순도: ≥90% (solid)
분자량: 668.66
분자식: C30H41FN4O12
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
loading

Caspase-3 inhibitor (Z-DEVD-FMK ) is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).


References

1. Schlegel, J. et al. 1996. J. Biol. Chem. 271(4): 1841-1844. PMID: 8567626
2. Nicholson, D.W. 1996. Nat. Biotechnol. 14(3): 297-301. PMID: 9630889
3. Masuda, Y. et al. 1997. Biochem. Biophys. Res. Commun. 234(3): 641-645. PMID: 9175767
4. Thornberry, N.A. and Lazebnik, Y. 1998. Science. 281(5381): 1312-1316. PMID: 9721091
5. Brockstedt, E., et al., 1998. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422
6. Henshall, D C., et al., 2000. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954
7. Kugawa, F., et al., 2000. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298
8. Nagarajah, N.S. et al. 2004. Mol. Cancer. 3(1): 38. PMID: 15613236
9. Cervantes, J. et al. 2008. Cell. Microbiol. 10(1): 41-52. PMID: 17662073

사용법 :
Pretreatment with an esterase is required when using with purified native or recombinant enzyme.

We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
Physical State :
Solid
시퀀스 :
Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-FMK
용해도 :
Soluble in DMSO (13.37 mg/ml).
저장 :
Store at -20° C
비등점 :
~914.2° C at 760 mmHg (Predicted)
밀도 :
~1.3 g/cm3 (Predicted)
굴절률 :
n20D 1.51 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](CCC(=O)OC)NC(=O)[[email protected]](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

SDS(MSDS)다운로드

분석증명서

PDF문서를 열람,
프린트와 코멘트를 작성하려면 Adobe Acrobat Reader가 필요합니다.

Caspase-3 Inhibitor 억제제 (CAS 210344-95-9)  논문정보

다른 사용자의 Caspase-3 Inhibitor 억제제 (CAS 210344-95-9)사용법보기. 클릭하여 PubMed entry보기 .

인용 1 to 10 of 52 합계

PMID: # 33618169  Wu, SW.|Su, CH.|Ho, YC.|Huang-Liu, R.|Tseng, CC.|Chiang, YW.|Yeh, KL.|Lee, SS.|Chen, WY.|Chen, CJ.|Li, YC.|Lee, CY.|Kuan, YH.| et al. 2021. Ecotoxicol Environ Saf. 213: 112062.

PMID: # 30904799  Zhao, W.|Li, H.|Hou, Y.|Jin, Y.|Zhang, L.| et al. 2019. World Neurosurg. 127: e346-e352.

PMID: # 31189945  Chambers, JS.|Brend, T.|Rabbitts, TH.| et al. 2019. Sci Rep. 9: 8553.

PMID: # 30795621  Nováková, J.|Talacko, P.|Novák, P.|Vališ, K.| et al. 2019. Cells. 8:

PMID: # 30692621  Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.

PMID: # 31035052  Huang, WC.|Gu, PY.|Fang, LW.|Huang, YL.|Lin, CF.|Liou, CJ.| et al. 2019. Phytomedicine. 61: 152852.

PMID: # 30161272  Chen, XB.|Li, W.|Chu, AX.| et al. 2019. J. Cell. Biochem. 120: 470-480.

PMID: # 31313541  Bishayee, K.|Habib, K.|Sadra, A.|Huh, SO.| et al. 2019. Cell. Physiol. Biochem. 53: 258-280.

PMID: # 29670107  Parida, PK. et al. 2018. Cell Death Dis. 9: 448.

PMID: # 30131570  Lee, BS.|Kim, YS.|Kim, HJ.|Kim, DH.|Won, HR.|Kim, YS.|Kim, CH.| et al. 2018. Sci Rep. 8: 12520.

인용 1 to 10 of 52 합계
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 106ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;