Caspase-1 inhibitor I CAS: 143313-51-3
MF: C23H32N4O8
MW: 492.52
An inhibitor of caspase-1, caspase-4, and caspase-5.

Caspase-1 inhibitor I (CAS 143313-51-3)

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Alternate Names: N-Ac-Tyr-Val-Ala-Asp-CHO; Ac-YVAD-CHO
Application Caspase-1 inhibitor I is an inhibitor of caspase-1, caspase-4, and caspase-5
CAS 등록번호: 143313-51-3
순도: ≥95%
분자량: 492.52
분자식: C23H32N4O8
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Caspase-1 Inhibitor I (Ac-YVAD-CHO, also designated L-709049) is a potent, specific, reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Ac-YVAD-CHO has been shown to strongly inhibit anti-APO-1 induced apoptosis in L929-APO-1 cells. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.

Additional caspase-1 inhibitors available:
caspase-1 inhibitor (sc-3069)
caspase-1 inhibitor VI (sc-3071)
Caspase-1 Inhibitor II (sc-300323)
Caspase-1 Inhibitor IV (sc-300324)


References

1. Brenner, B., et al. 1998. Cell Death Differ. 5: 29-37. PMID: 10200443
2. Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273: 32608-32613. PMID: 9829999
3. Hilbi, H., et al. 1998. J. Biol. Chem. 273: 32895-32900. PMID: 9830039
4. Thornberry, N.A, et al. 1998. Science. 281: 1312-1316. PMID: 9721091
5. Schlegel, J., et al. 1996. J. Biol. Chem. 271: 1841-1844. PMID: 8567626
6. Enari, M., et al. 1995. Nature. 375: 78-81. PMID: 7536900
7. Walker, N.P., et al. 1994. Cell. 78: 343-352. PMID: 8044845
8. Thornberry, N.A., et al. 1992. Nature. 356: 768-774. PMID: 1574116

사용법 :
Aqueous solutions should not be stored more than 1 day.
Physical State :
Solid
용해도 :
Soluble in DMSO (5 mg/ml), water (5 mg/ml) at 25° C, ethanol (~30 mg/ml), DMF (~30 mg/ml), and PBS(pH 7.2) (~5 mg/ml).
저장 :
Store at -20° C
녹는점 :
349.84° C (Predicted)
비등점 :
~937.75° C at 760 mmHg (Predicted)
밀도 :
~1.3 g/cm3 (Predicted)
굴절률 :
n20D 1.55 (Predicted)
IC50 :
Caspase-1: IC50 = 8.4 nM (human); PBMC : IC50 = 1.2 µM (human); Interleukin-1 beta: IC50 = 2 µM (human)
Ki 데이타 :
recombinant caspase-1: Ki= 200 pM (human); Caspase-1: Ki= 9 nM (mouse)
pK Values :
pKb: 4.20 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00237123
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C=O)NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](CC1=CC=C(C=C1)O)NC(=O)C

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Caspase-1 inhibitor I (CAS 143313-51-3)  논문정보

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PMID: # 29446207  Zhao, H.|Huang, H.|Alam, A.|Chen, Q.|Suen, KC.|Cui, J.|Sun, Q.|Ologunde, R.|Zhang, W.|Lian, Q.|Ma, D.| et al. 2018. Am. J. Transplant. 18: 1890-1903.

PMID: # 26901245  Xia, X. et al. 2016. Chemical research in toxicology. 29: 421-9.

PMID: # 27628063  Winges, A. et al. 2016. Graefes Arch. Clin. Exp. Ophthalmol. 254: 2387-2400.

PMID: # 26086368  Liang, Y. et al. 2015. Brain Res. 1622: 43-50.

PMID: # 24340123  Tavares, AH. et al. 2013. PLoS Negl Trop Dis. 7: e2595.

PMID: # 17235324  Park, HJ. et al. 2007. J Invest Dermatol. 127(5): 1210-1216.

PMID: # 28436935  J. Clin. Invest. 127: 2222-2234.

PMID: # 32721574  Toxicol. Lett.

PMID: # 32742397  Exp Ther Med. 1675-1681.

PMID: # 29209318  Front Immunol. 1572.

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