Bupropion HCl CAS: 31677-93-7
MF: C13H18ClNO•HCl
MW: 276.2
An inhibitor of dopamine and SLC6A2.

Bupropion HCl (CAS 31677-93-7)

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Alternate Names: 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propane, monohydrochloride
Application Bupropion HCl is an inhibitor of dopamine and SLC6A2
CAS 등록번호: 31677-93-7
순도: ≥99%
분자량: 276.2
분자식: C13H18ClNO•HCl
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Bupropion HCl is a non-selective inhibitor of dopamine and SLC6A2 (Ki values are 1.4 μM for SLC6A2, 2.8 μM for dopamine, and 45 μM for serotonin). Bupropion also inhibits neuronal nicotinic acetylcholine receptors. Bupropion HCl is an inhibitor of AChR, DAT and ST.


References

1. Cooper, B.R., et al. 1980. J. Pharmacol. Exp. Ther. 215: 127-134. PMID: 6778989
2. Lerman, C., et al. 2005. J. Clin. Oncol. 23: 311-323. PMID: 15637394
3. Silverstone, P.H., et al. 2008. Ann Gen Psychiatry. 7: 11. PMID: 18706108
4. Papakostas, G.I., et al. 2008. J Clin Psychiatry. 69: 1287-1292. PMID: 18605812
5. Henshall, D.C., et al. 2009. Neuropsychiatr Dis Treat. 5: 189-206. PMID: 19557114

Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in water (>25 mg/ml), ethanol 193mg/ml, 0.1 N HCl 333 mg/ml
저장 :
Store at 4° C
녹는점 :
236-238° C
Ki 데이타 :
serotonin transporter : Ki= 45 µM; dopamine transporter: Ki= 2.8 µM; norepinephrine transporters: Ki= 1.4 µM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
UG8858000
PubChem CID :
Merck Index :
14: 1499
MDL Number :
MFCD00055209
EC Number :
250-759-9
SMILES :
CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Cl

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분석증명서

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Bupropion HCl (CAS 31677-93-7)  논문정보

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PMID: # 25616031  Hall, BJ. et al. 2015. Pharmacology, biochemistry, and behavior. 130: 84-9.

PMID: # 25249693  Wu, J. et al. 2014. Drug Metab. Dispos. 42: 2058-67.

PMID: # 23751335  Writer, JH. et al. 2013. Sci. Total Environ. 461-462: 519-27.

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