Aurora Kinase/Cdk 억제제 CAS: 443797-96-4
MF: C15H12F2N6O3S CH3CN
MW: 435.4
A cell-permeable, reversible, ATP-competitive kinase inhibitor.

Aurora Kinase/Cdk 억제제 (CAS 443797-96-4)

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Alternate Names: JNJ-7706621, 4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide
Application Aurora Kinase/Cdk Inhibitor is (JNJ-7706621) a cell-permeable, reversible, ATP-competitive kinase inhibitor
CAS 등록번호: 443797-96-4
순도: ≥97%
분자량: 435.4
분자식: C15H12F2N6O3S CH3CN
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Aurora Kinase/Cdk inhibitor (JNJ-7706621) is a cell-permeable triazolylsulfonamido compound that acts as a reversible, ATP-competitive kinase inhibitor with selectivity towards ARKs (IC50 = 11 and 15 nM for ARK-1 (Aurora-A) and ARK-2 (Aurora-B), respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdc2 (Cdk1)/B, Cdk2/A, and Cdk2/E, respectively). Aurora Kinase/Cdk Inhibitor displays antitumor properties (IC50 in the range of 112-514 nM against various human cancer cell lines).


References

1. Emanuel, S. et al. 2005. Cancer Res. 65(19): 9038-9046. PMID: 16204078
2. Lin, R. et al. 2005. J. Med. Chem. 48(13): 4208-4211. PMID: 15974571
3. Seamon, J.A. et al. 2006. Mol. Cancer Ther. 5(10): 2459-2467. PMID: 17041089

Physical State :
Solid
용해도 :
Soluble in DMSO.
저장 :
Store at 4° C
IC50 :
Aurora-A: IC50 = 11 nM; Aurora-B: IC50 = 15 nM; Cdk1/B: IC50 = 9 nM; Cdk2/A: IC50 = 4 nM; Cdk2/E: IC50 = 3 nM; cancer cell lines: IC50 = 112 - 514 nM (human)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :
CC#N.Nc1nc(Nc2ccc(cc2)S(=O)(=O)N)nn1C(=O)c1c(F)cccc1F

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