10058-F4 CAS: 403811-55-2
MF: C12H11NOS2
MW: 249.35
A c-Myc inhibitor and apoptosis inducer.

10058-F4 (CAS 403811-55-2)

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10058-F4 is rated 5.0 out of 5 by 1.
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Alternate Names: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Application 10058-F4 is a c-Myc inhibitor and apoptosis inducer
CAS 등록번호: 403811-55-2
순도: ≥95%
분자량: 249.35
분자식: C12H11NOS2
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* Refer to Certificate of Analysis for lot specific data (including water content).
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10058-F4 is a c-Myc inhibitor that prevents c-Myc/Max dimerization. c-Myc is a proto-oncogene that plays an important role in cell proliferation, differentiation, and apoptosis. 10058-F4 has been shown to arrest cell growth at G0/G1 phase. Experiments show that extended exposure to 10058-F4 causes apoptosis via upregulation of Bax, expression of cytoplasmic Cytochrome C, down-regulation of Bcl-2, and cleavage of caspase-3,-7, and -9. This compound has been found to also upregulate cyclin-dependent kinase inhibitors, p21 and p27.


References

1. Huang, M.J., et al. 2006. Exp. Hematol. 34: 1480-1489. PMID: 17046567
2. Lin, C.P., et al. 2007. Anticancer Drugs. 18: 161-170. PMID: 17159602
3. Guo, J., et al. 2009. Cancer Chemother. Pharmacol. 63: 615-625. PMID: 18509642

Physical State :
Solid
용해도 :
Soluble in DMSO (up to 100 mM) or ethanol (up to 20 mM).
저장 :
Store at 4° C
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
PubChem CID :
SMILES :
CCC1=CC=C(C=C1)/C=C/2\\C(=O)NC(=S)S2

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10058-F4 (CAS 403811-55-2)  논문정보

다른 사용자의 10058-F4 (CAS 403811-55-2)사용법보기. 클릭하여 PubMed entry보기 .

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PMID: # 33919657  Kim, SH.|Kang, BC.|Seong, D.|Lee, WH.|An, JH.|Je, HU.|Cha, HJ.|Chang, HW.|Kim, SY.|Kim, SW.|Han, MW.| et al. 2021. Biomolecules. 11:

PMID: # 28402964  Ren, X. et al. 2017. Oncotarget. 8: 40958-40966.

PMID: # 28765944  Zhang, J.|Song, N.|Zang, D.|Yu, J.|Li, J.|Di, W.|Guo, R.|Zhao, W.|Wang, H.| et al. 2017. Mol Med Rep. 16: 4089-4094.

PMID: # 26312753  Mushtaq, M. et al. 2015. PLoS ONE. 10: e0136142.

PMID: # 23857601  Xu, M. et al. 2013. Clin. Cancer Res. 19: 4697-705.

PMID: # 23389829  Han, H. et al. 2013. Hepatology. 57: 2378-89.

PMID: # 23563689  Will, B.|Vogler, TO.|Bartholdy, B.|Garrett-Bakelman, F.|Mayer, J.|Barreyro, L.|Pandolfi, A.|Todorova, TI.|Okoye-Okafor, UC.|Stanley, RF.|Bhagat, TD.|Verma, A.|Figueroa, ME.|Melnick, A.|Roth, M.|Steidl, U.| et al. 2013. Nat. Immunol. 14: 437-45.

PMID: # 31712778  Leukemia.

PMID: # 27864144  Biochem. Biophys. Res. Commun. 482: 556-562.

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