Z-VDVAD-FMK MF: C32H46FN5O11
MW: 695.73
An irreversible inhibitor of Caspase-2.

Z-VDVAD-FMK

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別名: Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
アプリケーション: Z-VDVAD-FMK is an irreversible inhibitor of Caspase-2
Molecular Weight: 695.73
Molecular Formula: C32H46FN5O11
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Z-VDVAD-FMK (Caspase-2 inhibitor) is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. In a study of 7-ketocholesterol (sc-210630)-induced cell death and the association with polar lipid accumulation, the effects of Z-VDVAD-FMK on the lipid profile was evaluated by staining with Nile Red (sc-203747). Z-VDVAD-FMK has also been shown to inhibit programmed macrophage cell death induced by Brucella species gram-negative bacteria.

Purity: Single spot by TLC.


参考文献

1. Vejux, A. et al. 2007. Cytometry A. 71(8): 550-562. PMID: 17458884
2. Chen, F. and He, Y. 2009. PLoS ONE. 4(8): e6830. PMID: 19714247

用法 :
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (13.91 mg/ml), and DMSO/DMF (20 mM).
保存方法 :
Store at -20° C
Boiling Point :
980.10° C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD03452881
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](CC(=O)OC)NC(=O)[[email protected]](C(C)C)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

分析表

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Z-VDVAD-FMK  参考文献

他の人がZ-VDVAD-FMKをどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 4 of 4 合計

PMID: # 24204395  Wu, CC. et al. 2013. Evidence-based complementary and alternative medicine : eCAM. 2013: 548929.

PMID: # 19118032  Trougakos, IP. et al. 2009. Clin. Cancer Res. 15: 48-59.

PMID: # 19154411  Lee, JC. et al. 2009. Cancer science. 100: 503-13.

PMID: # 17082817  Hanoux, V. et al. 2007. Cell Death Differ. 14: 671-81.

引用 1 to 4 of 4 合計
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