Tyrphostin 47 CAS: 122520-86-9
MF: C10H8N2O2S
MW: 220.25
A potent inhibitor of EGFR kinase activity.

Tyrphostin 47 (CAS 122520-86-9)

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別名: RG-50864;Tyrphostin AG-213
アプリケーション: Tyrphostin 47 is a potent inhibitor of EGFR kinase activity
CAS 番号: 122520-86-9
Purity: >97%
Molecular Weight: 220.25
Molecular Formula: C10H8N2O2S
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Tyrphostin 47 is a protein tyrosine kinase inhibitor particularly potent against epidermal growth factor receptor (EGFR) kinase activity. Tyrphostin 47 has been observed to inhibit GTPase activity of transducin and the homologous insulin receptor kinase. It has also been found to also inhibit hyperactive motility of hamster spermatozoa. Tyrphostin 47 interferes with the proximal EGFR signaling pathway, causes G1-S transition arrest, and induces apoptosis in the human MCF-7 breast cancer cell line. In vero cell cultures, this product induced cell death and p38 MAPK phosphorylation.


参考文献

1. Gazit, A., et al. 1989. J. Med. Chem. 32: 2344-2352. PMID: 2552117
2. Turbov, J.M., et al. 2002. J Surg Oncol. 79: 17-29. PMID: 11754373
3. Ikeda, M., et al. 2006. Eur. J. Pharmacol. 546: 36-39. PMID: 16919262
4. Mariappa, D., et al. 2006. Mol. Reprod. Dev. 73: 215-225. PMID: 16220544

Physical State :
Solid
Solubility :
Soluble in ethanol (20 mg/ml), DMSO (20 mg/ml), 1:1 DMSO:PBS (~0.5 mg/ml,pH 7.2), DMF (~15 mg/ml), and acetone.
保存方法 :
Store at -20° C
Melting Point :
175.04° C (Predicted)
Boiling Point :
~474.5° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20/D 1.78
IC50 :
EGFR: IC50 = 2.4 µM; PDGFR: IC50 = 3.5 µM; p210bcr-abl: IC50 = 5.9 µM; insulin receptor: IC50 = 640 µM; protein kinase C: IC50 = 60 µM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00133902
Beilstein Registry :
6508337
SMILES :
C\\1=CC(=O)C(=C/C1=C\\C(=C(\\N)/S)\\C#N)O

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Tyrphostin 47 (CAS 122520-86-9)  参考文献

他の人がTyrphostin 47 (CAS 122520-86-9)をどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 4 of 4 合計

PMID: # 27872081  Guyett, PJ. et al. 2017. Antimicrob. Agents Chemother. 61:

PMID: # 12117110  Lorenzo, PL. et al. 2002. Equine Vet. J. 34: 378-382.

PMID: # 2788167  Lyall, RM. et al. 1989. J. Biol. Chem. 264: 14503-14509.

PMID: # 25715600  Ermakov, AM. et al. Biofizika. 59: 552-7.

引用 1 to 4 of 4 合計
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