TLCK hydrochloride CAS: 4238-41-9
MF: C14H21ClN2O3S•HCl
MW: 369.3

TLCK hydrochloride (CAS 4238-41-9)

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別名: TLCK hydrochloride is also known as Tosyllysine Chloromethyl Ketone Hydrochloride.
アプリケーション: TLCK hydrochloride is an active site-directed agent and irreversible inhibitor of trypsin-like serine proteases.
CAS 番号: 4238-41-9
Purity: ≥95%
Molecular Weight: 369.3
Molecular Formula: C14H21ClN2O3S•HCl
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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TLCK hydrochloride, or Tosyllysine Chloromethyl Ketone hydrochloride, is an active site-directed agent that irreversibly inhibits trypsin-like serine proteases such as granzyme D and tryptase. Cysteine proteinases and other enzymes may be inhibited by TLCK hydrochloride through non-selectively acting with thiol groups. To prevent proteolytic degradation, TLCK hydrochloride may be employed in protein purification protocols. TLCK hydrochloride selectively inactivates clostripain obtained from C. histolyticum. TLCK hydrochloride also inhibits other proteases including plasmin, thrombin, and papain and some kinases including PKC. TLCK hydrochloride inhibits LPS-induced expression of COX-2 in macrophages.


参考文献

1. Urban, M.K., et al. 1979. Biochemistry. 18: 3952-3960. PMID: 486404

2. Jenne, D.E. and Tschopp, J. 1988. Immunol. Rev. 103: 53-71. PMID: 3292396

3. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215: 721-729. PMID: 7488014

4. Abate, A., et al. 1998. Prostaglandins Other Lipid Mediat. 56: 277-290. PMID: 9990673

Physical State :
Solid
Sequence :
Nα-Tosyl-Lys-chloromethylketone⋅HCl
Solubility :
Soluble in methanol (50 mg/ml), DMSO (5 mM), water,Stock solutions at concentrations up to 10 mM can be prepared in aqueous buffers with a pH of 6.0 or lower. TLCK is very unstable in buffers with a pH higher then 6 and will decompose rapidly. PBS(pH 7.2) (~5 mg/ml), and DMF (~20 mg/ml).
保存方法 :
Store at -20° C
Melting Point :
160-161° C
Boiling Point :
509.8° C at 760 mmHg
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
XT5160000
PubChem CID :
MDL Number :
MFCD00065395
EC Number :
224-266-4
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)N[[email protected]@H](CCCCN)C(=O)CCl.Cl

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TLCK hydrochloride (CAS 4238-41-9)  参考文献

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引用 1 to 2 of 2 合計

PMID: # 24973403  Moon, HG. et al. 2014. American journal of physiology. Lung cellular and molecular physiology. 307: L326-37.

PMID: # 31296534  J. Cell Biol. 218: 2782-2796.

引用 1 to 2 of 2 合計
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