m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred secondary detection reagent for TBL1 Antibody (H-3) for WB applications. This reagent is now offered in a bundle with TBL1 Antibody (H-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
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Labware ships FedEx Ground free of charge to the contiguous US
TBL1 Antibody (H-3) is a high quality monoclonal TBL1 antibody (also designated TBL1 antibody) suitable for the detection of the TBL1 protein of mouse, rat and human origin. TBL1 Antibody (H-3) is available as both the non-conjugated anti-TBL1 antibody form, as well as multiple conjugated forms of anti-TBL1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TBL1, for transducin β-like 1, is a ubiquitously expressed protein that contains six distinct β-transducin repeats, known also as WD40 repeats, within the C-terminal domain. Transducin β-like 1 Y-linked protein (TBL1Y), also designated F-box-like/WD-repeat protein, and transducin β-like 1 X protein (TBL1X), also known as SMAP55, are nuclear F-box-like proteins. They are important in the ubiquitin/19S proteasome complex recruitment to nuclear receptor-regulated transcription units. TBL1X is a part of the N-CoR repressor complex together with N-CoR1, N-CoR2, HDAC3, TBL1R, CORO2A and GPS2. It is also a component of the E3 ubiquitin ligase complex. TBL1X, which can interact with Histones H2B, H3a and H4, is similar to TBL1Y but is localized on chromosome Xp22.3. Defects in TBL1X may cause an X-linked human disorder called ocular albinism with late-onset sensorineural deafness (OASD). TBL1Y is an X-degenerate gene that is homologous to TBL1X. TBL1Y, a single-copy gene, localizes to human chromosome Yp11.2 in the male-specific region of chromosome Y (MSY). This region of the Y chromosome does not engage in X-Y crossover events. TBL1Y is primarily expressed in fetal brain and prostate. TBL1X and TBL1Y are crucial in nuclear receptor mediated transcription activation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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