SRT1720 CAS: 1001645-58-4
MF: C25H23N7OS•HCl
MW: 506.02
A selective SIRT1 activator.

SRT1720 (CAS 1001645-58-4)

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別名: SRT 1720 Hydrochloride; N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydrochloride
アプリケーション: SRT1720 is a selective SIRT1 activator
CAS 番号: 1001645-58-4
Purity: ≥98%
Molecular Weight: 506.02
Molecular Formula: C25H23N7OS•HCl
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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SRT1720 is an NAD-dependent deacetylase sirtuin-1 (SIRT1) activator (EC50 = 0.16 μM), highly selective for SIRT1 over SIRT2 or SIRT3. Studies in yeast suggest that sirtuins may be involved in epigentic gene silencing and deactylation of proteins that regulate the cell cycle.


参考文献

1. Milne, J. C., et al. 2007. Nature. 450(7170): 712-716. PMID: 18046409

2. Chauhan, D., et al. 2011. Br. J. Haematol. 155(5): 588-598. PMID: 21950728

3. Suzuki, K., et al. 2012. Oncol. Rep. 27(6): 1726-1732. PMID: 22470132

4. Cao, L., et al. 2013. Braz. J. Med. Biol. Res. 46(8):659-669. PMID: 24036938

5. Nguyen, G. T., et al. 2013. Acta. Crystallogr. D. Biol. Crystallogr. 69(Pt 8): 1423-1432. PMID: 23897466.

6. Fan, H., et al. 2013. Kidney. Int. 83(3): 404-413. PMID: 23302720

7. Mitchell, S. J., et all. 2014. Cell Rep. 6(5): 836-843. PMID: 24582957

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (< 1 mg/mL at 25° C), DMSO (38 mg/mL at 25° C), and ethanol (< 1 mg/mL at 25° C).
保存方法 :
Store at -20° C
Melting Point :
209° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
SMILES :
C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl

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SRT1720 (CAS 1001645-58-4)  参考文献

他の人がSRT1720 (CAS 1001645-58-4)をどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 10 of 12 合計

PMID: # 30149019  Salazar-González, RA. et al. 2018. Biochem. Pharmacol. 156: 340-347.

PMID: # 30209341  Lee, J. et al. 2018. Sci Rep. 8: 13676.

PMID: # 29308302  Saidi, D.|Cheray, M.|Osman, AM.|Stratoulias, V.|Lindberg, OR.|Shen, X.|Blomgren, K.|Joseph, B.| et al. 2018. Oncoimmunology. 7: e1382790.

PMID: # 25902914  Zhao, K. et al. 2015. J Hematol Oncol. 8: 41.

PMID: # 26068191  2015. PLoS ONE. 10: e0129972.

PMID: # 23726949  Cheng, Y. et al. 2013. Eur. J. Pharmacol. 715: 219-29.

PMID: # 28295567  J Pineal Res.

PMID: # 28601780  Redox Biol. 301-309.

PMID: # 31717879  Mar Drugs. 17:

PMID: # 32421926  FEBS Open Bio.

引用 1 to 10 of 12 合計
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