SL-327 CAS: 305350-87-2
MF: C16H12F3N3S
MW: 335.35
A selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations.

SL-327 (CAS 305350-87-2)

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別名: Mek-1/Mek-2 Inhibitor
アプリケーション: SL-327 is a selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations
CAS 番号: 305350-87-2
Purity: ≥98%
Molecular Weight: 335.35
Molecular Formula: C16H12F3N3S
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* Refer to Certificate of Analysis for lot specific data (including water content).
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SL-327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively). This compound has been shown to block hippocampal LTP via inhibition of the MAPK/ERK cascade, which prevents CREB and Elk-1 phosphorylation, and LTP-dependent gene induction, resulting in rapidly decaying LTP, while being uncompetitive with respect to ATP. SL-327 has also been shown to inhibit ERK1, MEK-3/p38, MEK-4, JNK, and PKC activities when used at higher concentrations.


参考文献

1. Atkins, C.M., et al. 1998. Nat. Neurosci. 1: 602-609. PMID: 10196568
2. Scherle, P.A., et al. 2000. J. Biol. Chem. 275: 37086-37092. PMID: 10969080
3. Davis, S., et al. 2000. J. Neurosci. 20: 4563-4572. PMID: 10844026
4. Watabe, A.M., et al. 2000. J. Neurosci. 20: 5924-5931. PMID: 10934239
5. Valjent, E., et al. 2000. J. Neurosci. 20: 8701-8709. PMID: 11102476
6. Wang, H., et al. 2001. Biochem. Biophys. Res. Commun. 286: 869-874. PMID: 11527379
7. Ohno, M., et al. 2001. Nat. Neurosci. 4: 1238-1243. PMID: 11713472
8. Hetman, M., et al. 2002. J. Biol. Chem. 277: 49577-49584. PMID: 12393899
9. Salzmann, J., et al. 2003. Br. J. Pharmacol. 140: 831-838. PMID: 14517176
10. Wang, X., et al. 2003. J. Pharmacol. Exp. Ther. 304: 172-178. PMID: 12490588

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/mL), and ethanol (25 mg/mL). Insoluble in water.
保存方法 :
Store at -20° C
Melting Point :
127-128.2° C
Boiling Point :
~512.6° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.63
IC50 :
MEK1: IC50 = 0.18 µM; MEK2: IC50 = 0.22 µM; Proto-oncogene c-JUN: IC50 = 2.03 µM (human); Dual specificity mitogen-activated protein kinase kinase 4: IC50 = > 10 µM (human)
pK Values :
pKb: 4.47
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD06411432
SMILES :
C1=CC=C(C(=C1)/C(=C(\\N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F

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SL-327 (CAS 305350-87-2)  参考文献

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引用 1 to 7 of 7 合計

PMID: # 28396222  Zhang, L.|Xu, P.|Wang, X.|Zhang, M.|Yan, Y.|Chen, Y.|Zhang, L.|Zhang, L.| et al. 2017. Int. J. Biochem. Cell Biol. 87: 69-76.

PMID: # 27470338  Chen, Z. et al. 2016. Biomed. Pharmacother. 82: 49-53.

PMID: # 25197927  Zhang, M. et al. 2014. Cell Transplant. 23: 1061-73.

PMID: # 23582261  Zhang, M. et al. 2014. Cell Transplant. 23: 1061-1073.

PMID: # 32490727  Biosci. Biotechnol. Biochem. 1-11.

PMID: # 32768192  Biochem. Biophys. Res. Commun.

PMID: # 31852685  Development. 147:

引用 1 to 7 of 7 合計
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