Shikonin CAS: 517-89-5
MF: C16H16O5
MW: 288.3
A naphthoquinone derivative with angiogenesis inhibitor properties.

Shikonin (CAS 517-89-5)

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アプリケーション: Shikonin is a naphthoquinone derivative with angiogenesis inhibitor properties
CAS 番号: 517-89-5
Purity: ≥98%
Molecular Weight: 288.3
Molecular Formula: C16H16O5
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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Shikonin is a naturally occurring active chemical found in the root of Lithospermum erythrorhizon and used as a Chinese herb. The compound is a naphthoquinone derivative and has been shown to have anti-inflammatory and anti-tumor properties, as well as alter chemokine expression and function. Angiogenesis studies have shown that Shikonin can inhibit proliferation and migration of endothelial cells, block integrin αvβ3 expression, and inhibit B16 melanoma- and tumor necrosis factor-alpha-inuced angiogenesis in mice. Shikonin can down-regulate protein and mRNA expression of CKR-5 (CCR5), a primary HIV-1 coreceptor, in macrophages in HIV studies. Shikonin is an inhibitor of PKM2.


参考文献

1. Wang, W.J., et al. 1994. Yao Xue Xue Bao. 29: 161-165. PMID: 8079645
2. Hisa, T., et al. 1998. Anticancer Res. 18: 783-790. PMID: 9615720
3. Chen, X., et al. 2003. Antimicrob. Agents Chemother. 47: 2810-2816. PMID: 12936978
4. Nigorikawa, K., et al. 2006. Mol. Pharmacol. 70: 1143-1149. PMID: 16804092
5. Kim, Y.O., et al. 2010. Korean J. Physiol. Pharmacol. 14: 199-204. PMID: 20827333

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
保存方法 :
Store at 4° C
Melting Point :
202.18° C (Predicted)
Boiling Point :
~567.4° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
HCT-116: IC50 = 230 nM (human); HL-60 : IC50 = 440 nM (human); HepG2 : IC50 = 240 nM (human); K562/ADR cells : IC50 = 670 nM (human); TPEN: IC50 = 2.7 µM
pK Values :
pKa: 7.34 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
RTECS :
QL8000200
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
SMILES :
CC(=CC[[email protected]](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C

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Shikonin (CAS 517-89-5)  参考文献

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引用 1 to 10 of 11 合計

PMID: # 34211568  Jia, Y.|Li, Z.|Wang, T.|Fan, M.|Song, J.|Lv, P.|Jin, W.| et al. 2021. Evid Based Complement Alternat Med. 2021: 5564246.

PMID: # 34607978  Piao, MJ.|Han, X.|Kang, KA.|Fernando, PDSM.|Herath, HMUL.|Hyun, JW.| et al. 2021. Biomol Ther (Seoul).

PMID: # 29925224  Han, X.|Kang, KA.|Piao, MJ.|Zhen, AX.|Hyun, YJ.|Kim, HM.|Ryu, YS.|Hyun, JW.| et al. 2019. Biomol Ther (Seoul). 27: 41-47.

PMID: # 30788651  Bergamaschi, D.|Vossenkamper, A.|Lee, WYJ.|Wang, P.|Bochukova, E.|Warnes, G.| et al. 2019. Apoptosis.

PMID: # 29175336  Lee, HL. et al. 2018. Methods. 134-135: 56-66.

PMID: # 27223482  Gupta, B. et al. 2016. Can. J. Physiol. Pharmacol. 94: 788-96.

PMID: # 24248858  Wang, L. et al. 2014. Neurochemical research. 39: 97-106.

PMID: # 20827333  Kim, YO. et al. 2010. Korean J. Physiol. Pharmacol. 14: 199-204.

PMID: # 11704659  Tomoda, K. et al. 2002. J. Biol. Chem. 277: 2302-10.

PMID: # 30718913  Nat. Immunol. 20: 313-325.

引用 1 to 10 of 11 合計
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