Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
RNF8 Antibody (B-2) is a high quality monoclonal RNF8 antibody (also designated Ring Finger Protein 8 antibody, UBC13/UEV-Interacting Ring Finger Protein antibody, C3HC4-Type Zinc Finger Protei antibody, HRNF8 or Ring Finger Protein 8, E3 Ubiquitin Protein Ligase antibody) suitable for the detection of the RNF8 protein of mouse, rat and human origin. RNF8 Antibody (B-2) is available as both the non-conjugated anti-RNF8 antibody form, as well as multiple conjugated forms of anti-RNF8 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The RING finger motif is a specialized DNA-binding zinc finger domain found in many transcriptional regulatory proteins. The ring finger protein (RNF) family includes any protein containing the signature RING finger motif. RNF8 is a ubiquitously expressed nuclear RING finger protein that acts as an E3 ubiquitin-protein ligase. It is required for the ubiquitination of some nuclear proteins and promotes their subsequent degradation. The heterodimeric ubiquitin-conjugating enzyme UBC13 interacts with RNF8, and they co-localize in the nucleus. RNF8 may regulate mediation of UBC13 polyubiquitylation by elongating the ubiquitin chains. RNF8 also binds to Retinoid X receptor alpha (RXRα), a member of the steroid hormone receptor superfamily. It increases RXRα-mediated transactivation of the RXRα-responsive element (RXRE) promoter in a dose-dependent manner, suggesting that RNF8 is a regulator of RXRα-mediated transcriptional activity.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences