Reserpine CAS: 50-55-5
MF: C33H40N2O9
MW: 608.68
An inhibitor of transport of biogenic amines into adrenal chromaffin granules.

Reserpine (CAS 50-55-5)

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別名: Serpalan; Serpasil; Hiserpia; Serpanray; Serpivite; Apoplon
アプリケーション: Reserpine is an inhibitor of transport of biogenic amines into adrenal chromaffin granules
CAS 番号: 50-55-5
Purity: ≥98%
Molecular Weight: 608.68
Molecular Formula: C33H40N2O9
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Reserpine has displayed a capacity to inhibit the transport of biogenic amines into synaptic vesicles and adrenal chromaffin granules. The mechanism behind this inhibition has been illuminated as an irreversible binding to the vesicular amine transporter. Furthermore, Reserpine has been reported to interfere with dopamine transporter activity and potently inhibit synaptosomal dopamine uptake. Reserpine is an inhibitor of VMAT 2.


参考文献

1. Schuldiner, S., et al. 1993. J. Biol. Chem. 268: 29-34. PMID: 8416935
2. Heslop, K.E., et al. 1999. Neuropharmacology. 38: 883-891. PMID: 10465692
3. Metzger, R.R., et al. 2002. Eur. J. Pharmacol. 456: 39-43. PMID: 12450567

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), chloroform (10 mg/ml), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
保存方法 :
Store at room temperature
Melting Point :
264.5° C
Boiling Point :
~700.1° C at 760 mmHg (Predicted)
Density :
1.33 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D -106.2°, c = 1 in chloroform; α23/D -118°, c = 1 in chloroform; α26/D -168°, c = 0.62 in DMF; α26/D -164°, c = 0.96 in pyridine
IC50 :
Mdr-1: IC50 = 0.5 µM (human); Plasmodium falciparum: IC50 = 0.79 µM; Sodium channel alpha subunits; brain (Types I, II, III): IC50 = 1.6 µM (human); Quinolone resistance protein norA: IC50 = 7 µM (Staphylococcus aureus); BSEP: IC50 = 10.2 µM (human)
Ki Data :
Synaptic vesicular amine transporter: Ki= 1 nM (bovine); Mdr-1: Ki= 100 nM (human); MOR-1: Ki= 1.69 µM (human); P-glycoprotein 3: Ki= 4.03 µM (mouse)
pK Values :
pKa: 6.6, pKb: 7.25 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
ZG0350000
PubChem CID :
Merck Index :
14: 8145
MDL Number :
MFCD00005091
EC Number :
200-047-9
Beilstein Registry :
102014
SMILES :
COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC

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Reserpine (CAS 50-55-5)  参考文献

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引用 1 to 1 of 1 合計

PMID: # 22508860  Yamamoto, T. et al. 2012. Infect. Immun. 80: 2323-32.

引用 1 to 1 of 1 合計
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