PPACK dihydrochloride CAS: 142036-63-3
MF: C21H31ClN6O3•2HCl
MW: 523.88

PPACK dihydrochloride (CAS 142036-63-3)

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別名: PPACK dihydrochloride is also known as D-Phe-Pro-Arg-CMK.
アプリケーション: PPACK dihydrochloride is an irreversible, potent, selective inhibitor of thrombin and its downstream effects.
CAS 番号: 142036-63-3
Molecular Weight: 523.88
Molecular Formula: C21H31ClN6O32HCl
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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PPACK dihydrochloride is known to be an irreversible and potent inhibitor of thrombin. PPACK dihydrochloride is shown to inhibit thrombin activation of progelatinase A. In vivo pretreatment with PPACK dihydrochloride has been shown to inhibit thrombin-induced cerebral thromboembolism. PPACK dihydrochloride is also known to act as an anticoagulant in platelet-rich plasma. PPACK dihydrochloride is also known as D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone, D-Phe-Pro-Arg-CMK, and D-Phe-Pro-Arg-chloromethylketone.


参考文献

1. Liu, J.T. 1994. Eur. J. Pharmacol. 264(2): 183-190. PMID: 7851481 2. Rahr, H.B. 1994. Thromb. Res. 73(5): 279-284. PMID: 8016814 3. Zucker, S. 1995. J. Biol. Chem. 270(40): 23730-23738. PMID: 7559545 4. Kereiakes, D.J. 2001. J. Thromb. Thrombolysis. 12

Physical State :
Solid
Sequence :
D-Phe-Pro-Arg-chloromethylketone
Solubility :
Soluble in water (0.3 mg/ml at 25° C).
保存方法 :
Store at -20° C
Refractive Index :
n20D 1.64
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
SMILES :
C1C[[email protected]](N(C1)C(=O)[[email protected]@H](CC2=CC=CC=C2)N)C(=O)N[[email protected]@H](CCCN=C(N)N)C(=O)CCl.Cl.Cl

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PPACK dihydrochloride (CAS 142036-63-3)  参考文献

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引用 1 to 10 of 21 合計

PMID: # 34122402  Garishah, FM.|Rother, N.|Riswari, SF.|Alisjahbana, B.|Overheul, GJ.|van Rij, RP.|van der Ven, A.|van der Vlag, J.|de Mast, Q.| et al. 2021. Front Immunol. 12: 629167.

PMID: # 30722079  Yu, X. et al. 2019. Thromb. Haemost. 119: 586-593.

PMID: # 31423724  Ferrière, S.|Kawecki, C.|Ottavi, JF.|Denis, CV.|Kauskot, A.|Christophe, OD.|Lenting, PJ.| et al. 2019. J Thromb Haemost. 17: 2035-2046.

PMID: # 30560697  Rigg, RA. et al. 2019. Platelets. 30: 126-135.

PMID: # 30460241  Tullemans, BME. et al. 2018. Front Cardiovasc Med. 5: 142.

PMID: # 29785664  Zilberman-Rudenko, J.|Zhao, FZ.|Reitsma, SE.|Mitrugno, A.|Pang, J.|Shatzel, JJ.|Rick, B.|Tyrrell, C.|Hasan, W.|McCarty, OJT.|Schreiber, MA.| et al. 2018. Cardiovasc Eng Technol. 9: 515-527.

PMID: # 28083075  Zilberman-Rudenko, J.|Itakura, A.|Maddala, J.|Baker-Groberg, SM.|Vetter, R.|Tucker, EI.|Gruber, A.|Gerdes, C.|McCarty, OJ.| et al. 2016. Cell Mol Bioeng. 9: 496-508.

PMID: # 26725377  Zhu, S. et al. 2016. J. Thromb. Haemost. 14: 1070-81.

PMID: # 27816455  Streng, AS. et al. 2016. Biochem. Biophys. Res. Commun. 481: 165-168.

PMID: # 25418346  Jiménez-Alcázar, M. et al. 2015. J. Thromb. Haemost. 13: 732-42.

引用 1 to 10 of 21 合計
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