(+)-Pilocarpine hydrochloride CAS: 54-71-7
(+)-Pilocarpine hydrochloride is a nonselective cholinergic agonist.

(+)-Pilocarpine hydrochloride (CAS 54-71-7)

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別名: Adsorbocarpine; Almocarpine; Isopto Carpine
アプリケーション: (+)-Pilocarpine hydrochloride is a nonselective cholinergic agonist
CAS 番号: 54-71-7
Purity: ≥98%
Molecular Weight: 244.72
Molecular Formula: C11H16N2O2•HCl
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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(+)-Pilocarpine hydrochloride is a nonselective AChR (cholinergic) agonist that acts under high junctional concentrations of the neurotransmitter. Also, a parasympathomimetic agent with the muscarinic effects of acetylcholine. (+)-Pilocarpine hydrochloride is an activator of mAChR M.


参考文献

1. Cavalheiro, E.A. 1995. Ital J Neurol Sci. 16: 33-37. PMID: 7642349

2. ten Berge, R.E. et al. 1996. Naunyn Schmiedebergs Arch. Pharmacol. 354: 606-611. PMID: 8938659

3. Mayorga, A.J., et al. 1999. Eur. J. Pharmacol. 364: 7-11. PMID: 9920179

4. Dubé, C., et al. 2000. Exp. Neurol. 162: 146-157. PMID: 10716895

Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml, with heat as needed), alcohol, chloroform (slightly), DMSO (75 mM), and ethanol.
保存方法 :
Store at 4° C
Melting Point :
202-205° C (lit.)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Muscarinic acetylcholine receptor: IC50 = 68 nM (rat); Muscarinic acetylcholine receptor M1: IC50 = 0.96 µM (rat); Muscarinic acetylcholine receptor M1: EC5050 = 6.9 µM (mouse); mAChR M1: EC5050 = 8.79 µM (human); Muscarinic acetylcholine receptor M2: IC50 = 8.8 µM (rat)
Ki Data :
Muscarinic acetylcholine receptor: Ki= 82.9 nM (rat); Muscarinic acetylcholine receptor M1: Ki= 3.1 µM (rat); Muscarinic acetylcholine receptor M2: Ki= 9.8 µM (rat)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
TK1450000
PubChem CID :
Merck Index :
14: 7424
MDL Number :
MFCD00012722
EC Number :
200-212-5
Beilstein Registry :
4034491
SMILES :
CCC1C(COC1=O)CC2=CN=CN2C.Cl

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(+)-Pilocarpine hydrochloride (CAS 54-71-7)  参考文献

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引用 1 to 3 of 3 合計

PMID: # 8028781  Maslanski, JA. et al. 1994. Neurosci. Lett. 168: 225-228.

PMID: # 6634931  Al-Badr, AA. et al. 1983. Pharmazie. 38: -.

PMID: # 28476050  Cornea. 719-724.

引用 1 to 3 of 3 合計
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