PD 198306 CAS: 212631-61-3
MF: C18H16F3IN2O2
MW: 476.2
A cell-permeable compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2.

PD 198306 (CAS 212631-61-3)

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アプリケーション: PD 198306 is a cell-permeable compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2
CAS 番号: 212631-61-3
Purity: >98%
Molecular Weight: 476.2
Molecular Formula: C18H16F3IN2O2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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PD 198306 is a cell-permeable amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk′s, and PI 3-Kγ (IC50 >1.0 μM).


参考文献

Pelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582. Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751. Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
保存方法 :
Store at 4° C
Melting Point :
218.74° C (Predicted)
Boiling Point :
513.15° C (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
MEK1/2: IC50 = 8 nM; ERK: IC50 = > 1 µM; c-Src: IC50 = > 4 µM; cdks: IC50 = >4 µM; PI 3-kinase γ : IC50 = >10 µM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
SMILES :
CC1=C(C=CC(=C1)I)NC2=C(C(=C(C=C2C(=O)NOCC3CC3)F)F)F

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PD 198306 (CAS 212631-61-3)  参考文献

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引用 1 to 3 of 3 合計

PMID: # 23167655  Chang, Y. et al. 2012. J. Agric. Food Chem. 60: 11909-18.

PMID: # 21794976  Vergara, D. et al. 2011. Cancer Lett. 310: 1-8.

PMID: # 12794826  Pelletier, JP. et al. 2003. Arthritis Rheum. 48: 1582-1593.

引用 1 to 3 of 3 合計
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