Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Cyclin-dependent kinase 5 (Cdk5) is found in its active form only in neuronal cells. Like other members of the Cdk family, Cdk5 catalytic activity is influenced by both p35 binding and phosphorylation. The serine 159 residue is the major phosphorylation target for Cdk5-activating kinases. Cdk5 requires both p35 binding and phosphorylation at serine 159 for maximal rates of activation. In addition, casein kinase I, but not casein kinase II, can phosphorylate and activate Cdk5 in vitro. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 and enhances p35/Cdk5 kinase activity. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cdk5 and Abl enzyme substrate (CABLES). Phosphorylation of either serine 159 or tyrosine 15 dramatically increases Cdk5 activation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.