MEK Inhibitor I CAS: 297744-42-4
MF: C21H18N4OS
MW: 374.46
A vinylogous cyanamide that has the ability to act as a selective and potent inhibitor of MEK.

MEK Inhibitor I (CAS 297744-42-4)

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アプリケーション: MEK Inhibitor I is a vinylogous cyanamide that has the ability to act as a selective and potent inhibitor of MEK
CAS 番号: 297744-42-4
Purity: ≥95%
Molecular Weight: 374.46
Molecular Formula: C21H18N4OS
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* Refer to Certificate of Analysis for lot specific data (including water content).
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MEK Inhibitor I is a cell-permeable, pyridine-containing, vinylogous cyanamide that has the ability to act as a selective and potent inhibitor of MEK with little activity towards MKK3 and MKK4. The compound displays significant affinity only towards ATP-bound MEK (i.e. noncompetitive with respect to ATP) and the demonstrated inhibition is noncompetitive with respect to ERK. Compared to U0126 in aqueous solutionsMEK Inhibitor I demonstrates superior potency, solubility, and stability. Additionally shown to protect against phorbol ester-mediated ear edema in mice.


参考文献

1. Wityak, J., et al. 2004. Bioorg. Med. Chem. Lett. 14: 1483-1486. PMID: 15006386

Physical State :
Solid
Solubility :
DMSO and methanol
保存方法 :
Store at -20° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
SMILES :
C1=CC=C(C(=C1)N)S/C(=C(\\C#N)/C2=CC(=CC=C2)C(C3=CC=NC=C3)O)/N

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MEK Inhibitor I (CAS 297744-42-4)  参考文献

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引用 1 to 1 of 1 合計

PMID: # 25886889  Shubin, AV. et al. 2015. BMC Cell Biol. 16: 4.

引用 1 to 1 of 1 合計
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