McN-A-343 CAS: 55-45-8
MF: C14H18ClN2O2•Cl
MW: 317.2
A selective agonist of mAChR M1.

McN-A-343 (CAS 55-45-8)

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別名: (4-Hydroxy-2-butynyl)-1-trimethylammonium-3-chlorocarbanilate chloride
アプリケーション: A selective agonist of mAChR M1
CAS 番号: 55-45-8
Molecular Weight: 317.2
Molecular Formula: C14H18ClN2O2•Cl
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* Refer to Certificate of Analysis for lot specific data (including water content).
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McN-A-343 is a selective agonist of mAChR M1. McN-A-343 has been used to probe the identity of muscarinic receptors responsible for contractile and relaxant response mediation in various biological systems. It also shows agonist activity at mAChR M4.


参考文献

1. Davies, R.H., et al. 2001. J. Pharm. Pharmacol. 53: 487-496. PMID: 11341365
2. Liu, J., et al. 2002. J. Pharmacol. Exp. Ther. 302: 397-405. PMID: 12065743
3. Stengel, P.W., et al. 2003. J. Pharmacol. Exp. Ther. 304: 675-682. PMID: 12538821
4. Figueroa, K.W., et al. 2009. J. Pharmacol. Exp. Ther. 328: 331-342. PMID: 18824613
5. Yang, J.J., et al. 2010. J. Neurophysiol. 103: 1397-1409. PMID: 20071625

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (>25 mg/mL)
保存方法 :
Store at room temperature
IC50 :
Muscarinic acetylcholine receptor M1: IC50 = 355 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M2: IC50 = 5304 nM (Rattus norvegicus); Oryctolagus cuniculus: IC50 = 659 nM; Muscarinic acetylcholine receptor: IC50 = 64 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M1: EC5050 = 3500 nM (human); Muscarinic acetylcholine receptor M3: EC5050 = 6500 nM (human)
Ki Data :
Muscarinic acetylcholine receptor M1: Ki= 500 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M2: Ki= 500 nM (Rattus norvegicus); Muscarinic acetylcholine receptor: Ki= 18 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M3: Ki= 500 nM (Rattus norvegicus)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
BR0318000
PubChem CID :
MDL Number :
MFCD00055068
SMILES :
C[N+](C)(C)CC#CCOC(=O)NC1=CC(=CC=C1)Cl.[Cl-]

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McN-A-343 (CAS 55-45-8)  参考文献

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引用 1 to 4 of 4 合計

PMID: # 20071625  Yang, JJ. et al. 2010. J. Neurophysiol. 103: 1397-1409.

PMID: # 12538821  Stengel, PW. et al. 2003. J. Pharmacol. Exp. Ther. 304: 675-682.

PMID: # 12065743  Liu, J. et al. 2002. J. Pharmacol. Exp. Ther. 302: 397-405.

PMID: # 11341365  Davies, RH. et al. 2001. J. Pharm. Pharmacol. 53: 487-496.

引用 1 to 4 of 4 合計
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