Lipoxin A4 CAS: 89663-86-5
MF: C20H32O5
MW: 352.46
A trihydroxy fatty acid produced through 15-HETE metabolism.

Lipoxin A4 (CAS 89663-86-5)

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別名: 5(S),6(R)-Lipoxin A4; 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
アプリケーション: Lipoxin A4 is a trihydroxy fatty acid produced through 15-HETE metabolism
CAS 番号: 89663-86-5
Purity: ≥95%
Molecular Weight: 352.46
Molecular Formula: C20H32O5
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lipoxin A4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. Lipoxin A4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 µM. Lipoxin A4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition (potent human PKC (protein kinase C) activator; inhibits cytotoxicity of natural killer cells), and monocyte migration and adhesion. Biosynthesis occurs in human leukocytes and rat alveolar macrophages. Transcellular biosynthesis occurs via interaction of human neutrophils or granulocytes and platelets. Produced in human nasal polyps and bronchial tissue. Stimulates vasodilation and antagonizes LTD4-induced vasoconstriction. Induces glomerular hyperperfusion and hyperfiltration. Inhibits LTB4- or FMLP-induced leukocyte chemotaxis and blocks the mobilization of Ca2+ and IP3. Inhibits LTB4-induced inflammation in the hamster cheek pouch. Activates protein kinase C13. Regulates human myelopoiesis. Lipoxin A4 is an activator of GPR.


参考文献

1. Serhan, C.N., et al. 1984. Proc. Natl. Acad. Sci. U.S.A. 81: 5335-5339. PMID: 6089195
2. Hansson, A., et al. 1986. Biochem. Biophys. Res. Commun. 134: 1215-1222. PMID: 2418836
3. Serhan, C.N., et al. 1986. J. Biol. Chem. 261: 16340-16345. PMID: 3097008
4. Badr, K.F., et al. 1987. Biochem. Biophys. Res. Commun. 145: 408-414. PMID: 3593345
5. Ueda, N., et al. 1987. Biochem. Biophys. Res. Commun. 149: 1063-1069. PMID: 3122743
6. Ramstedt, U., et al. 1987. J. Immunol. 138: 266-270. PMID: 3782800
7. Kim, S.J. 1988. Biochem. Biophys. Res. Commun. 150: 870-876. PMID: 3124841
8. Edenius, C., et al. 1988. Biochem. Biophys. Res. Commun. 157: 801-807. PMID: 2849436
9. Lefer, A.M., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 8340-8344. PMID: 3186729
10. Hedqvist, P., et al. 1989. Acta Physiol. Scand. 137: 571-572. PMID: 2557732
11. Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 3438-3442. PMID: 2541448
12. Grandordy, B.M., et al. 1990. Biochem. Biophys. Res. Commun. 167: 1022-1029. PMID: 2157419
13. Edenius, C., et al. 1990. FEBS Lett. 272: 25-28. PMID: 2172016
14. Fiore, S. and Serhan, C.N 1990. J. Exp. Med. 172: 1451-1457. PMID: 2172436
15. Stenke, L., et al. 1991. Biochem. Biophys. Res. Commun. 180: 255-261. PMID: 1930222
16. Lee, T.H., et al. 1991. Biochem. Biophys. Res. Commun. 180: 1416-1421. PMID: 1659416
17. Fiore, S., et al. 1992. J. Biol. Chem. 267: 16168-16176. PMID: 1322894
18. Maddox, J.F. and Sethan,C.N. 1996. J. Exp. Med. 183: 137-146. PMID: 8551217

用法 :
Store as supplied at -80° C for up to 1 year.
Formulation :
A solution in ethanol
Appearance :
Oil dissolved in ethanol
Physical State :
Liquid
Solubility :
Soluble in ethanol, DMSO (≥50 mg/ml), DMF (≥50 mg/ml), and PBS (pH 7.2) (≥1 mg/ml).
保存方法 :
Store at -80° C
Boiling Point :
78° C
Refractive Index :
n20D 1.54
pK Values :
pKa: 4.67
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
2
PubChem CID :
MDL Number :
MFCD00065845
EC Number :
200-578-6
SMILES :
CCCCCC(/C=C/C=C/C=C/C=C/C(C(CCCC(=O)O)O)O)O

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Lipoxin A4 (CAS 89663-86-5)  参考文献

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引用 1 to 2 of 2 合計

PMID: # 21885654  Russell, R.|Gori, I.|Pellegrini, C.|Kumar, R.|Achtari, C.|Canny, GO.| et al. 2011. FASEB J. 25: 4326-37.

PMID: # 31784636  Sci Rep. 9: 17894.

引用 1 to 2 of 2 合計
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