L-alpha-Phosphatidylinositol-3,4,5-trisphosphate, Dipalmitoyl-, Heptaammonium Salt MF: C41H75O22P4•7NH4
MW: 1170.2
A Ca2+-insensitive PKCδ, PKCε, and PKCη activator.

L-α-Phosphatidylinositol-3,4,5-trisphosphate, Dipalmitoyl-, Heptaammonium Salt

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別名: PI-3,4,5-P3, 7NH4, PIP3, Dipalmitoyl-
アプリケーション: L-α-Phosphatidylinositol-3,4,5-trisphosphate, Dipalmitoyl-, Heptaammonium Salt is a Ca2+-insensitive PKCδ, PKCε, and PKCη ac
Purity: ≥98%
Molecular Weight: 1170.2
Molecular Formula: C41H75O22P47NH4
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).

PI-3,4,5-P3, 7NH4, PIP3, Dipalmitoyl- activates Ca2+-insensitive PKCδ, PKCε, and PKCη isozymes. Binds to the general receptor for phosphoinositide-1 (GRP1) protein through a plekstrin homology (PH) domain. Has also been shown to produce actin reorganization, membrane ruffling and increase motility of NIH/3T3 cells.


参考文献

1. Toker, A., et al., 1994. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. The Journal of biological chemistry. 269(51): 32358-67. PMID: 7798235
2. Ireton, K., et al., 1996. A role for phosphoinositide 3-kinase in bacterial invasion. Science (New York, N.Y.). 274(5288): 780-2. PMID: 8864117
3. Derman, M P., et al., 1997. The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. The Journal of biological chemistry. 272(10): 6465-70. PMID: 9045671
4. Klarlund, J K., et al., 1997. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science (New York, N.Y.). 275(5308): 1927-30. PMID: 9072969

Physical State :
Solid
Solubility :
Soluble in DMSO (1 mg/ml).
保存方法 :
Store at -20° C
Boiling Point :
>300° C
Refractive Index :
n20D ~1.53 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
PubChem CID :
SMILES :
[N+].[N+].[N+].[N+].[N+].[N+].[N+].CCCCCCCCCCCCCCCC(=O)OCC(CO[P](=O)([O-])O[[email protected]]1[[email protected]](O)[[email protected]@H](O[P](=O)([O-])[O-])[[email protected]](O[P](=O)([O-])[O-])[[email protected]@H](O[P](=O)([O-])[O-])[[email protected]]1O)OC(=O)CCCCCCCCCCCCCCC

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分析表

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L-alpha-Phosphatidylinositol-3,4,5-trisphosphate, Dipalmitoyl-, Heptaammonium Salt  参考文献

他の人がL-alpha-Phosphatidylinositol-3,4,5-trisphosphate, Dipalmitoyl-, Heptaammonium Saltをどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 1 of 1 合計

PMID: # 20617170  Fausther-Bovendo H et al. 2010. PLoS Pathog. 6: :e1000975.

引用 1 to 1 of 1 合計
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