Kynurenic acid CAS: 492-27-3
Kynurenic acid is an antagonist of NMDA and AMPA/kainate receptors.

Kynurenic acid (CAS 492-27-3)

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別名: 4-Hydroxyquinoline-2-carboxylic acid
アプリケーション: Kynurenic acid is an antagonist of NMDA and AMPA/kainate receptors
CAS 番号: 492-27-3
Purity: ≥97%
Molecular Weight: 189.17
Molecular Formula: C10H7NO3
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Kynurenic acid is a metabolite of tryptophan in mammals via the kynurenine pathway. Studies have observed that Kynurenic acid acts as a ligand to the GPR35 G protein-coupled receptor. The binding of Kynurenic acid to GPR35 has been noted to affect calcium mobilization and inositol phosphatase synthesis and may indicate potential signaling functions by Kynurenic acid via the GPR35 receptor. Additionally reported to be a broad spectrum, excitatory amino acid (EAA) antagonist. Other studies have reported that Kynurenic acid acts as an antagonist to mammalian ionotropic glutamate receptors especially NMDA (N-methyl-D-aspartate receptors).Kynurenic acid is an inhibitor of AChR α7, GluR and GlyR.

Also available as a Kynurenic acid, sodium salt (sc-358835)


参考文献

1. Pittaluga, A., et al. 1997. J. Pharmacol. Exp. Ther. 283: 82-90. PMID: 9336311

2. Wong, A.Y et al. 2003. J. Neurosci. 23: 4868-4877. PMID: 12832509

3. Brooks, V.L., et al. 2004. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287: R1359-R1368. PMID: 15319216

4. Nasif, F.J., et al. 2005. J. Neurosci. 25: 3674-3679. PMID: 15814798

5. Wang, J., et al. 2006. J. Biol. Chem. 281: 22021-22028. PMID: 16754668

6. Le Floc′h, N., et al. 2010. Amino Acids. [Epub ahead of print]. PMID: 20872026

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (partly), hot alcohol, DMSO (75 mM), 0.1 M NaOH (50 mg/ml), and methanol.
保存方法 :
Store at 4° C
Melting Point :
275° C (lit.)(dec.)
Boiling Point :
358.36° C at 760 mmHg (Predicted)
Density :
1.43 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
Glutamate NMDA receptor: IC50 = 13.8 µM (rat); Glutamate (NMDA) receptor subunit zeta 1: IC50 = 40.2 µM (rat); Glutamate receptor ionotropic, AMPA: IC50 = 101 µM (rat); GPR35: EC5050 = 152 µM (human); Rattus norvegicus: IC50 = 167 µM
Ki Data :
Glutamate (NMDA) receptor subunit zeta 1: Ki= 5.4 µM (rat); Vesicular glutamate transporter 3: Ki= 1.3 mM (rat)
pK Values :
pKa: 3.49 (Predicted), pKb: 0.36 (Predicted)
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
RTECS :
VB2080000
PubChem CID :
Merck Index :
14: 5327
MDL Number :
MFCD00006753
EC Number :
207-751-5
Beilstein Registry :
147451
SMILES :
C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O

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Kynurenic acid (CAS 492-27-3)  参考文献

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引用 1 to 5 of 5 合計

PMID: # 34025023  Suzuki, T.|Morishita, H.|Fukuhara, K.| et al. 2021. J Clin Biochem Nutr. 68: 215-220.

PMID: # 27060260  Kim, IS.|Hwang, JH.|Hirano, M.|Iwata, H.|Kim, EY.| et al. 2016. Comp Biochem Physiol C Toxicol Pharmacol. 187: 1-9.

PMID: # 23467467  Uwai, Y. et al. 2013. Int J Tryptophan Res. 6: 1-6.

PMID: # 22108572  Uwai, Y. et al. 2012. Pharmacol. Res. 65: 254-60.

PMID: # 32563159  Ecotoxicol. Environ. Saf. 110835.

引用 1 to 5 of 5 合計
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