Indatraline hydrochloride CAS: 96850-13-4
MF: C16H15Cl2N.HCl
MW: 328.67
An inhibitor of ST, DAT, and SLC6A2.

Indatraline hydrochloride (CAS 96850-13-4)

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別名: (±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride; Lu 19-005
アプリケーション: Indatraline hydrochloride is an inhibitor of ST, DAT, and SLC6A2
CAS 番号: 96850-13-4
Molecular Weight: 328.67
Molecular Formula: C16H15Cl2N.HCl
補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
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Indatraline hydrochloride is a strong monoamine uptake inhibitor which inhibits the transporters ST (serotonin/SERT) (Ki = 0.42 nM), DAT (dopamine) (Ki = 1.7 nM), and SLC6A2 (noradrenalin/NET) (Ki = 5.8 nM).


参考文献

1. Hyttel, J. and Larsen, J.J. 1985. J. Neurochem. 44: 1615-1622.
2. Negus, S.S., et al. 1999. J. Pharmacol. Exp. Ther. 291: 60-69.
3. Gu, X.H., et al. 2000. J. Med. Chem. 43: 4868-4876.

Physical State :
Solid
Solubility :
Soluble in water (25 mM), ethanol (50 mM), and DMSO (100 mM).
保存方法 :
Desiccate at 4° C
IC50 :
Plasmodium falciparum: IC50 = 3.98 µM
Ki Data :
ST: Ki= 0.42 nM; DAT: Ki= 1.7 nM; SLC6A2: Ki= 5.8 nM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00083178
SMILES :
CN[[email protected]@H]1C[[email protected]](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl

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