Hypothemycin CAS: 76958-67-3
MF: C19H22O8
MW: 378.37
An antifungal selective inhibitor of MEK.

Hypothemycin (CAS 76958-67-3)

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アプリケーション: Hypothemycin is an antifungal selective inhibitor of MEK
CAS 番号: 76958-67-3
Purity: ≥97%
Molecular Weight: 378.37
Molecular Formula: C19H22O8
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Hypothemycin exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes. Hypothemycin facilitates the ubiquitinylation process of cyclin D1. Hypothemycin has been identified as a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in in vitro studies.


参考文献

1. Sonoda, H., et al., 1999. Suppression of oncogenic transformation by hypothemycin associated with accelerated cyclin D1 degradation through ubiquitin-proteasome pathway. Life sciences. 65(4): 381-94. PMID: 10421424
2. Tanaka, H., et al., 1999. Antitumor efficacy of hypothemycin, a new Ras-signaling inhibitor. Japanese journal of cancer research : Gann. 90(10): 1139-45. PMID: 10595743
3. Camacho, R., et al., 1999. Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation. Immunopharmacology. 44(3): 255-65. PMID: 10598882
4. Zhao, A., et al., 1999. Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK. The Journal of antibiotics. 52(12): 1086-94. PMID: 10695671
5. Schirmer, Andreas., et al., 2006. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Proceedings of the National Academy of Sciences of the United States of America. 103(11): 4234-9. PMID: 16537514
6. Winssinger, Nicolas., et al., 2007. Chemistry and biology of resorcylic acid lactones. Chemical communications (Cambridge, England). (1): 22-36. PMID: 17279252

Physical State :
Solid
Derived From :
Phoma sp
Solubility :
Soluble in DMSO (10 mg/ml), and acetone. Insoluble in water, methanol, and deionized water.
保存方法 :
Store at -20° C
Melting Point :
251.29° C (Predicted)
Boiling Point :
~667.8° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Growth of HT29 cells: IC50 = 0.08 mM; Growth of HCT116 cells: IC50 = 0.90 mM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD08457932
SMILES :
CC1C/C=C/C(=O)C2C(O2)CC(C(C3=CC(=CC(=C3C(=O)O1)O)OC)O)O

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