GBR 12935 dihydrochloride CAS: 67469-81-2
MF: C28H34N2O•2HCl
MW: 487.51
A DAT and SLC6A2 inhibitor.

GBR 12935 dihydrochloride (CAS 67469-81-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 154ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
別名: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
アプリケーション: GBR 12935 dihydrochloride is a DAT and SLC6A2 inhibitor
CAS 番号: 67469-81-2
Molecular Weight: 487.51
Molecular Formula: C28H34N2O•2HCl
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

GBR 12935 dihydrochloride inhibits DAT (dopamine transporter) (Ki = 21.5 nM) and SLC6A2 (norepinephrine transporter) (Ki = 225 nM). GBR 12935 does not inhibit the serotonin transporter (Ki = 6.5 μM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.


参考文献

Andersen et al (1987) Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the dopamine uptake complex. J.Neurochem. 48 1887. Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter. Eur.J.Pharmacol.Mol.Pharmacol.Sect. 227 417. Reith et al (1994) GBR 12909 and 12935 block dopamine uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mM), and water (20 mg/ml).
保存方法 :
Desiccate at -20° C
Refractive Index :
n20D ~1.58 (Predicted)
Ki Data :
Serotonin transporter: Ki= 6.5 µM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00083175
SMILES :
C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl

Download SDS (MSDS)

分析表

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

GBR 12935 dihydrochloride (CAS 67469-81-2)  参考文献

他の人がGBR 12935 dihydrochloride (CAS 67469-81-2)をどのように使用したかをご覧ください。 エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 1 of 1 合計

PMID: # 33610553  Sorkina, T.|Cheng, MH.|Bagalkot, TR.|Wallace, C.|Watkins, SC.|Bahar, I.|Sorkin, A.| et al. 2021. J Biol Chem. 100430.

引用 1 to 1 of 1 合計
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 125ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;